中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
2期
166-169
,共4页
曹玉珠%刘兆国%单云龙%孙丽华%刘玉萍%韦忠红%祝娉婷%吴红雁%王爱云%陈文星%郑仕中%陆茵
曹玉珠%劉兆國%單雲龍%孫麗華%劉玉萍%韋忠紅%祝娉婷%吳紅雁%王愛雲%陳文星%鄭仕中%陸茵
조옥주%류조국%단운룡%손려화%류옥평%위충홍%축빙정%오홍안%왕애운%진문성%정사중%륙인
血小板%瘤栓%肿瘤血行转移%分子机制%治疗策略%临床应用
血小闆%瘤栓%腫瘤血行轉移%分子機製%治療策略%臨床應用
혈소판%류전%종류혈행전이%분자궤제%치료책략%림상응용
platelet%tumor embolus%tumor hematogenous spread%molecular mechanisms%therapy strategies%clinical ap-plication
肿瘤转移是恶性肿瘤最为重要的生物学特性之一，同时也是影响预后及导致治疗失败的主要因素。临床研究显示，恶性肿瘤患者的血小板数目较正常人及良性肿瘤患者明显升高，表明血小板可能参与了肿瘤的发生发展过程。进一步研究发现，血小板在肿瘤血行转移的过程中能够与肿瘤细胞相互作用形成瘤栓，逃避免疫监视，进而促进了肿瘤的转移。近年来，临床上已经开展了针对血小板治疗肿瘤转移的研究，同时，血小板促进肿瘤转移的相关作用机制也逐步地被揭示。该文对近年来血小板介导肿瘤血行转移的作用及其作用机制研究进展进行综述，探讨临床针对血小板治疗肿瘤转移的策略，为后续的科学研究及指导临床提供参考。
腫瘤轉移是噁性腫瘤最為重要的生物學特性之一，同時也是影響預後及導緻治療失敗的主要因素。臨床研究顯示，噁性腫瘤患者的血小闆數目較正常人及良性腫瘤患者明顯升高，錶明血小闆可能參與瞭腫瘤的髮生髮展過程。進一步研究髮現，血小闆在腫瘤血行轉移的過程中能夠與腫瘤細胞相互作用形成瘤栓，逃避免疫鑑視，進而促進瞭腫瘤的轉移。近年來，臨床上已經開展瞭針對血小闆治療腫瘤轉移的研究，同時，血小闆促進腫瘤轉移的相關作用機製也逐步地被揭示。該文對近年來血小闆介導腫瘤血行轉移的作用及其作用機製研究進展進行綜述，探討臨床針對血小闆治療腫瘤轉移的策略，為後續的科學研究及指導臨床提供參攷。
종류전이시악성종류최위중요적생물학특성지일，동시야시영향예후급도치치료실패적주요인소。림상연구현시，악성종류환자적혈소판수목교정상인급량성종류환자명현승고，표명혈소판가능삼여료종류적발생발전과정。진일보연구발현，혈소판재종류혈행전이적과정중능구여종류세포상호작용형성류전，도피면역감시，진이촉진료종류적전이。근년래，림상상이경개전료침대혈소판치료종류전이적연구，동시，혈소판촉진종류전이적상관작용궤제야축보지피게시。해문대근년래혈소판개도종류혈행전이적작용급기작용궤제연구진전진행종술，탐토림상침대혈소판치료종류전이적책략，위후속적과학연구급지도림상제공삼고。
Tumor metastasis is one of the most important biologi-cal characteristics of malignant tumor, and it is also the main factors that cause treatment failure and poor prognosis. Clinical studies have shown that the number of platelets in patients with malignant tumor increased more significantly than that in benign tumor patients and healthy people, which indicate that platelet might be involved in the development process of tumor. Further study found that in the process of cancer spreading to blood, platelet could interact with tumor cells to form tumor emboli, helped tumor cells escape from immune surveillance, thus pro-moted the tumor metastasis. In recent years, related mechanisms on platelets in promoting tumor metastasis were revealed gradual-ly, and several targeted therapies based on platelets were also carried out. This paper reviews the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms and discusses the therapy strategies that target platelet, which may provide references for follow-up research and clinical treat-ment.
