中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
2期
157-161,162
,共6页
缝隙连接%连接蛋白%神经系统%胶质细胞%神经病理性痛%缝隙连接阻断剂
縫隙連接%連接蛋白%神經繫統%膠質細胞%神經病理性痛%縫隙連接阻斷劑
봉극련접%련접단백%신경계통%효질세포%신경병이성통%봉극련접조단제
gap junction%connexin%nervous system%glial cells%neuropathic pain%gap junction blocker
缝隙连接是介导相邻细胞间物质转运、化学或电信号传递的专用跨膜通道，维持着细胞内环境的稳定。在神经系统中，缝隙连接不仅介导神经元和胶质细胞的胞间偶合，还参与病理条件下继发性损害。目前，研究证明缝隙连接在由神经系统损伤引起的神经病理性痛中发挥作用。对缝隙连接与神经病理性痛的关系进行研究有助于更深层次的了解神经病理性痛的发病机制，为治疗神经病理性痛提供新的研究方向。
縫隙連接是介導相鄰細胞間物質轉運、化學或電信號傳遞的專用跨膜通道，維持著細胞內環境的穩定。在神經繫統中，縫隙連接不僅介導神經元和膠質細胞的胞間偶閤，還參與病理條件下繼髮性損害。目前，研究證明縫隙連接在由神經繫統損傷引起的神經病理性痛中髮揮作用。對縫隙連接與神經病理性痛的關繫進行研究有助于更深層次的瞭解神經病理性痛的髮病機製，為治療神經病理性痛提供新的研究方嚮。
봉극련접시개도상린세포간물질전운、화학혹전신호전체적전용과막통도，유지착세포내배경적은정。재신경계통중，봉극련접불부개도신경원화효질세포적포간우합，환삼여병리조건하계발성손해。목전，연구증명봉극련접재유신경계통손상인기적신경병이성통중발휘작용。대봉극련접여신경병이성통적관계진행연구유조우경심층차적료해신경병이성통적발병궤제，위치료신경병이성통제공신적연구방향。
Gap junctions are specialized transmembrane channels that enable the direct exchange of materials and transfer chemical or electrical signaling between adjacent cells, thus maintaining cellular homeostasis. In the nervous system, gap junction chan-nels not only mediate intercellular coupling between neurons and between glial cells, but also can be involved in secondary dam-age under pathological conditions. Recently, some studies have shown that gap junctions play an important role in neuropathic pain caused by nervous system damage. Research on the role of gap junctions in neuropathic pain can contribute to a deeper un-derstanding of the pathogenesis of neuropathic pain, providing a new research direction for the treatment of neuropathic pain.
