CAJ | 학술논문

乙型肝炎病毒( HBV)感染是一种严重影响公共卫生与人体健康的全球性流行性疾病，尽管乙肝防治已有很大提高，但仍缺乏高效的药物与手段。研究表明，肝损伤、肝衰竭程度与HBV及宿主免疫系统相互作用存在复杂关系。因而详细地探明HBV生命周期和感染过程，为研究HBV药物靶点和制定新的抗病毒策略提供前期坚实的基础，意义重大。该文详细介绍HBV病毒复制机制，并系统地阐述近年来新发现的和潜在的药物靶点，为制备新型的抗HBV药物提供参考。
을형간염병독( HBV)감염시일충엄중영향공공위생여인체건강적전구성류행성질병，진관을간방치이유흔대제고，단잉결핍고효적약물여수단。연구표명，간손상、간쇠갈정도여HBV급숙주면역계통상호작용존재복잡관계。인이상세지탐명HBV생명주기화감염과정，위연구HBV약물파점화제정신적항병독책략제공전기견실적기출，의의중대。해문상세개소HBV병독복제궤제，병계통지천술근년래신발현적화잠재적약물파점，위제비신형적항HBV약물제공삼고。
Hepatits B virus( HBV) infection is a global epidemic which seriously harms the public health. In spite of the great progress in hepatits B prevention and treatment, there is few ef-fective medicine. Research findings show that liver damage and degree of liver failure are sophisticatedly related to the interaction between HBV and the immune response of host. All these make it important to know the replication mechanism and the contrac-tion process, in order to lay a preliminary solid foundation for studying HBV drug targets and making a new ant-virus strategy. This article aims to summarize HBV viral replication process, while focusing on the latest research findings about drug targets, to find a new kind of anti-HBV drugs, and to explore the under-lying mechanism of effective drugs.