中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
2期
149-151,152
,共4页
药物成瘾%单胺神经递质%5-羟色胺%去甲肾上腺素%多巴胺%奖赏系统
藥物成癮%單胺神經遞質%5-羥色胺%去甲腎上腺素%多巴胺%獎賞繫統
약물성은%단알신경체질%5-간색알%거갑신상선소%다파알%장상계통
drug addiction%monoamine neurotransmitter%5-hydroxytryptamine%norepinephrine%dopamine%brain reward system
药物成瘾是一种慢性复发性大脑疾病,各种成瘾性药物通过作用于奖赏系统,最终引起神经递质释放的改变,产生奖赏效应。其中,单胺类神经递质5-羟色胺(5-hydroxytryptamine,5-HT)、去甲肾上腺素( noradrenergic,NE)和多巴胺( dopamine,DA)在药物成瘾中起到重要作用,该文就单胺类神经递质在药物成瘾中的作用及机制进行综述。
藥物成癮是一種慢性複髮性大腦疾病,各種成癮性藥物通過作用于獎賞繫統,最終引起神經遞質釋放的改變,產生獎賞效應。其中,單胺類神經遞質5-羥色胺(5-hydroxytryptamine,5-HT)、去甲腎上腺素( noradrenergic,NE)和多巴胺( dopamine,DA)在藥物成癮中起到重要作用,該文就單胺類神經遞質在藥物成癮中的作用及機製進行綜述。
약물성은시일충만성복발성대뇌질병,각충성은성약물통과작용우장상계통,최종인기신경체질석방적개변,산생장상효응。기중,단알류신경체질5-간색알(5-hydroxytryptamine,5-HT)、거갑신상선소( noradrenergic,NE)화다파알( dopamine,DA)재약물성은중기도중요작용,해문취단알류신경체질재약물성은중적작용급궤제진행종술。
Drug addiction is a chronic recrudescent brain dis-ease. Various addictive drugs acting on the reward system result in rewarding effects through changes in neurotransmitter patholog-ical release. Among these monoamine neurotransmitters, 5-hydroxytryptamine, norepinephrine and dopamine play key roles in drug addiction. This paper reviews, from a comprehensive perspective, the roles which monoamine neurotransmitters play in the drug addiction and the process of getting addictive.
