CAJ | 학술논문

近年来，由于细菌耐药性问题越发严峻，开发新型抗菌制剂已经越来越受到重视。抗菌肽具有抗菌谱广，有别于抗生素的抗菌机制，能有效地抑杀真菌、病毒、寄生虫等，并能选择性的杀灭肿瘤细胞，不易产生耐药性，而对人畜毒副作用极小，构成宿主防御病原微生物入侵的第一道屏障，是机体免疫系统的重要成分，抗菌肽作为新药开发具有广阔的前景。本文主要就目前抗菌肽的分类、抗菌机制、临床应用等方面做简要介绍。
근년래，유우세균내약성문제월발엄준，개발신형항균제제이경월래월수도중시。항균태구유항균보엄，유별우항생소적항균궤제，능유효지억살진균、병독、기생충등，병능선택성적살멸종류세포，불역산생내약성，이대인축독부작용겁소，구성숙주방어병원미생물입침적제일도병장，시궤체면역계통적중요성분，항균태작위신약개발구유엄활적전경。본문주요취목전항균태적분류、항균궤제、림상응용등방면주간요개소。
Resistance of bacterial is an increasingly serious problem,which results in urgency for new type antibiotics develop-ment.Antimicrobial peptides (ABPs)have great clinical significance due to character of broad—spectrum antimicrobial activity and mechanisms different from traditional antibiotics, Several studies have shown that ABPs have effects on bacterial,virues and cancer cells,and are not easy to produce bacterial resistance. They form the first line of host defense against pathogenic infections,and they are key components of the ancient innate immune system. The review summarized the classification,mechanism,clinical uses,etc.