CAJ | 학술논문

制备一种温敏性凝胶型防晒化妆品并建立质量标准。方法：以 parsol 1789（丁基甲氧基二苯酰甲烷)，parsol 5000(3-4-甲基亚苄基樟脑)和parsol MCX(甲氧基肉桂酸辛酯)等为吸光剂，以纳米二氧化钛为屏蔽剂，以壳聚糖透明质酸温敏性水凝胶、二甲基硅油、十二烷基硫酸钠等为基质成分制备防晒化妆品，建立性状、pH、皮肤刺激性、稳定性、含量测定等质量标准。结果：制备的温敏性凝胶型防晒化妆品质地细腻，涂展性、稳定性良好、家兔试验无不良刺激反应；以HPLC法测定parsol 1789含量，在0.32256-1.6128μg范围内线性关系良好(r=0.9998)，平均回收率为98.93%, RSD =0.42%；SPF值测定结果均为25以上。结论：该温敏性凝胶型防晒化妆品制剂工艺可行，质量可控。
제비일충온민성응효형방쇄화장품병건립질량표준。방법：이 parsol 1789（정기갑양기이분선갑완)，parsol 5000(3-4-갑기아변기장뇌)화parsol MCX(갑양기육계산신지)등위흡광제，이납미이양화태위병폐제，이각취당투명질산온민성수응효、이갑기규유、십이완기류산납등위기질성분제비방쇄화장품，건립성상、pH、피부자격성、은정성、함량측정등질량표준。결과：제비적온민성응효형방쇄화장품질지세니，도전성、은정성량호、가토시험무불량자격반응；이HPLC법측정parsol 1789함량，재0.32256-1.6128μg범위내선성관계량호(r=0.9998)，평균회수솔위98.93%, RSD =0.42%；SPF치측정결과균위25이상。결론：해온민성응효형방쇄화장품제제공예가행，질량가공。
To esterblish the Preparation technology of a temperature sensitive gel type sunscreen cosmetics and the establish-ment of quality standard. Methods: The parsol 1789 (butyl methoxy-dibenzoyl methane), Parsol 5000 [3-(4'- methyl benzyli-dene)-d-1-camphor) and parsol MCX (octyl methoxycinnamate) were used as UV absorption, nano-titanium dioxide was used as shielding agents,chitosan hyaluronic acid temperature sensitive hydrogel, dimethyl silicone ,twelve sodium dodecyl were used to made sunscreen cream.The quality standard include characters, pH, skin irritation, stability, content determination were established. Re-sults: The prepared sunscreen cosmetics not only has good malleability and stability,but also has no stimulus response in domestic rabbit.The content of parsol 1789 was determined by HPLC with the good liner range was 0.32256-1.6128μg,(r=0.999 8,the average recovery was 98.93%, RSD = 0.42%.All the SPF of the cosmetics over 25. Conclusion: The preparation technology was feasible,the quality was controllable.