黑龙江医药
黑龍江醫藥
흑룡강의약
HEILONGJIANG MEDICAL JOURNAL
2015年
1期
49-51,52
,共4页
酒石酸美托洛尔%渗透泵控释片%片剂
酒石痠美託洛爾%滲透泵控釋片%片劑
주석산미탁락이%삼투빙공석편%편제
目的：研制酒石酸美托洛尔渗透泵控释片，对处方及工艺进行筛选并评价其体外释药行为。方法：对处方及工艺采用单因素考察方法进行筛选，然后采用正交试验方法，对处方进行优化。结果：所制备的酒石酸美托洛尔渗透泵控释片，工艺重现性较好；羟丙甲纤维素（HPMC）K15m的用量、PEG4000的用量和包衣增重对渗透泵片释放速率有明显的影响；所制备的酒石酸美托洛尔渗透泵控释片在12小时内有明显的零级释药特征。结论：此种处方工艺简单易行，体外释药曲线平稳恒定，可以克服和改善目前该普通制剂在临床应用方面的缺点和不足。
目的：研製酒石痠美託洛爾滲透泵控釋片，對處方及工藝進行篩選併評價其體外釋藥行為。方法：對處方及工藝採用單因素攷察方法進行篩選，然後採用正交試驗方法，對處方進行優化。結果：所製備的酒石痠美託洛爾滲透泵控釋片，工藝重現性較好；羥丙甲纖維素（HPMC）K15m的用量、PEG4000的用量和包衣增重對滲透泵片釋放速率有明顯的影響；所製備的酒石痠美託洛爾滲透泵控釋片在12小時內有明顯的零級釋藥特徵。結論：此種處方工藝簡單易行，體外釋藥麯線平穩恆定，可以剋服和改善目前該普通製劑在臨床應用方麵的缺點和不足。
목적：연제주석산미탁락이삼투빙공석편，대처방급공예진행사선병평개기체외석약행위。방법：대처방급공예채용단인소고찰방법진행사선，연후채용정교시험방법，대처방진행우화。결과：소제비적주석산미탁락이삼투빙공석편，공예중현성교호；간병갑섬유소（HPMC）K15m적용량、PEG4000적용량화포의증중대삼투빙편석방속솔유명현적영향；소제비적주석산미탁락이삼투빙공석편재12소시내유명현적령급석약특정。결론：차충처방공예간단역행，체외석약곡선평은항정，가이극복화개선목전해보통제제재림상응용방면적결점화불족。
Objective: To develop metoprolol tartrate osmotic pump tablets, prescription and processes for screening and evalua-tion of the in vitro release behavior. Method: The prescription and craft, and then using orthogonal experiment method to optimize the prescription. Results: Metoprolol tartrate prepared as osmotic pump tablets, better process reproducibility; hydroxypropyl methyl cel-lulose (HPMC) K15M the dosage, PEG4000 dosage and coating weight gain of the release rate of the osmotic pump tablets significant impact; metoprolol tartrate prepared as osmotic pump tablets within 12 hours zero-order release characteristics. Conclusions: Such prescription is a simple technique, stable in vitro release curve is constant, the ordinary preparations in clinical application of the shortcomings and deficiencies can be overcome and improve.
