中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
1期
32-34,35
,共4页
非瓣膜性房颤%缺血性脑卒中%回顾性分析%对照研究
非瓣膜性房顫%缺血性腦卒中%迴顧性分析%對照研究
비판막성방전%결혈성뇌졸중%회고성분석%대조연구
Non-valcular atrial fibrillation%Ischemic stroke%Retrospectively analyze%Controlled study
目的：分析非瓣膜性心房颤动（nonvalvular atrial fibrillation ，NVAF）患者缺血性脑卒中（ischemic stroke ，IS）的危险因素，为临床防治提供参考。方法回顾性分析2008‐01－2013‐05在我院治疗的NVAF患者临床资料，根据有无合并IS分为NVAFIS组（n＝14）和NVAF组（n＝79），将2组患者的一般情况，入院时超声、ECG、血脂、凝血功能、炎性因子等检查结果进行单因素分析，并将有意义的单因素纳入多因素Logistic回归分析，探讨NVAF患者发生IS的危险因素。结果与NVAF组比较，NVAFIS组患者60岁以上多见（71.4％），抗凝治疗比例低（28.6％），合并高血压（57.1％）或糖尿病（28.6％）比例更高，组间差异明显（P＜0.05）。NVAFIS组患者LAD水平、血脂中TC水平显著高于NVAF组，但凝血功能中INR显著低于NVAF组。Logistic多因素回归分析发现，年龄超过60岁，合并高血压、糖尿病，LAD增大，TC水平升高是NVAFIS的独立危险因素，而抗凝治疗，INR正常是保护因素（P＜0.05）。结论年龄超过60岁，合并高血压、糖尿病，LAD增大，TC水平升高是引起NVAFIS的独立危险因素。
目的：分析非瓣膜性心房顫動（nonvalvular atrial fibrillation ，NVAF）患者缺血性腦卒中（ischemic stroke ，IS）的危險因素，為臨床防治提供參攷。方法迴顧性分析2008‐01－2013‐05在我院治療的NVAF患者臨床資料，根據有無閤併IS分為NVAFIS組（n＝14）和NVAF組（n＝79），將2組患者的一般情況，入院時超聲、ECG、血脂、凝血功能、炎性因子等檢查結果進行單因素分析，併將有意義的單因素納入多因素Logistic迴歸分析，探討NVAF患者髮生IS的危險因素。結果與NVAF組比較，NVAFIS組患者60歲以上多見（71.4％），抗凝治療比例低（28.6％），閤併高血壓（57.1％）或糖尿病（28.6％）比例更高，組間差異明顯（P＜0.05）。NVAFIS組患者LAD水平、血脂中TC水平顯著高于NVAF組，但凝血功能中INR顯著低于NVAF組。Logistic多因素迴歸分析髮現，年齡超過60歲，閤併高血壓、糖尿病，LAD增大，TC水平升高是NVAFIS的獨立危險因素，而抗凝治療，INR正常是保護因素（P＜0.05）。結論年齡超過60歲，閤併高血壓、糖尿病，LAD增大，TC水平升高是引起NVAFIS的獨立危險因素。
목적：분석비판막성심방전동（nonvalvular atrial fibrillation ，NVAF）환자결혈성뇌졸중（ischemic stroke ，IS）적위험인소，위림상방치제공삼고。방법회고성분석2008‐01－2013‐05재아원치료적NVAF환자림상자료，근거유무합병IS분위NVAFIS조（n＝14）화NVAF조（n＝79），장2조환자적일반정황，입원시초성、ECG、혈지、응혈공능、염성인자등검사결과진행단인소분석，병장유의의적단인소납입다인소Logistic회귀분석，탐토NVAF환자발생IS적위험인소。결과여NVAF조비교，NVAFIS조환자60세이상다견（71.4％），항응치료비례저（28.6％），합병고혈압（57.1％）혹당뇨병（28.6％）비례경고，조간차이명현（P＜0.05）。NVAFIS조환자LAD수평、혈지중TC수평현저고우NVAF조，단응혈공능중INR현저저우NVAF조。Logistic다인소회귀분석발현，년령초과60세，합병고혈압、당뇨병，LAD증대，TC수평승고시NVAFIS적독립위험인소，이항응치료，INR정상시보호인소（P＜0.05）。결론년령초과60세，합병고혈압、당뇨병，LAD증대，TC수평승고시인기NVAFIS적독립위험인소。
Objective To analyze the risk factors of ischemic stroke of patients with non‐valvular atrial fibrillation (NVAF).Methods The clinical data of patients with NVAF in our hospital from January 2008 to May 2013 were retrospec‐tively analyzed.Patients with NVAF were divided into NVAFIS group (n=14) and NVAF group (n=79) according to whether have IS or not.The general condition ,ultrasonography ,ECG ,serum lipid ,coagulation function and inflammatory factor of two groups were analyzed by single factor analysis.The significant single factors were analyzed by logistic regression analysis to in‐vestigate the risk factors of patients with NVAF occurring.Results Compared with NVAF group ,NVAFIS group had the fol‐lowing characteristics:more than 60 years old (71.4% ) ,lower anticoagulant therapy rate (28.6% ) ,and combined with hyper‐tension or diabetes (57.1% or 28.6% ).Compared with NVAF group ,NVAFIS group had higher TC and lower INR lev‐el.Multivariate logistic regression analysis indicated that the elder age ,hypertension ,diabetes mellitus ,increased LAD and TC were some independent risk factors while anticoagulant therapy and normal INR were protective factors for patients with ische‐mic stroke.Conclusion More than 60 years old ,combined with hypertension or diabetes ,increased LAD AND TC level are in‐dependent risk factors for ischemic stroke of patients with NVAF.
