CAJ | 학술논문

目的：探析重型颅脑外伤后脑血管痉挛（CVS）和脑脊液一氧化氮（NO）及内皮素（ET‐1）水平的相关性。方法入选我院2012‐02—2014‐02收治的重型颅脑外伤后C V S患者124例作为观察对象，根据C V S严重程度分为重度组40例，中度组42例，轻度组42例，入选同期重型颅脑外伤后未发生C V S的40患者作为对照组，检测患者入院后1 d、3 d、5 d及7 d时双侧大脑中动脉（MCA）和颈内动脉颅外段（ICA）脑血流速度及脑脊液NO、ET‐1水平。结果 CVS各组NO浓度均显著低于对照组，且CVS重度组NO浓度显著低于中度组，中度组显著低于轻度组；ET‐1呈相反变化。结论颅脑外伤后CVS的发生可能与脑脊液中NO抑制，ET‐1升高，破坏血管舒张收缩平衡相关。
목적：탐석중형로뇌외상후뇌혈관경련（CVS）화뇌척액일양화담（NO）급내피소（ET‐1）수평적상관성。방법입선아원2012‐02—2014‐02수치적중형로뇌외상후C V S환자124례작위관찰대상，근거C V S엄중정도분위중도조40례，중도조42례，경도조42례，입선동기중형로뇌외상후미발생C V S적40환자작위대조조，검측환자입원후1 d、3 d、5 d급7 d시쌍측대뇌중동맥（MCA）화경내동맥로외단（ICA）뇌혈류속도급뇌척액NO、ET‐1수평。결과 CVS각조NO농도균현저저우대조조，차CVS중도조NO농도현저저우중도조，중도조현저저우경도조；ET‐1정상반변화。결론로뇌외상후CVS적발생가능여뇌척액중NO억제，ET‐1승고，파배혈관서장수축평형상관。
Objective To investigate the relationship between vasospasm (CVS) and NO ,ET‐1 level in cerebrospinal flu‐id (CSF) on patients with severe post‐craniocerebral trauma.Methods 124 patients with CVS after severe craniocerebral trau‐ma from February 2012 to February 2014 were divided into severe group (n=40) ,medium group (n=42) and mild group (n=40).40 patients without CVS after severe craniocerebral trauma in the same time were chosen as control group.The cerebral blood flow velocity (CBFV) in MCV and ICA ,and the NO ,ET‐1 levels in CSF at 1d ,3d ,5d and 7d after admission of all pa‐tients were detected. Results The NO concentration of CVS groups was lower than that of control group .There were the low‐est NO concentration in CVS severe group and the higher NO concentration in CVS mild group.The ET‐1 level changes of CVS groups had an opposite tendency with NO concentration changes.Conclusion The patients with CVS occurrence after cranioce‐rebral trauma may have a correlation with NO decreasing and ET‐1 increasing in CSF to destroy the balance between vasodila‐tion and vasoconstriction.