临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
2期
89-91
,共3页
胃炎%幽门螺杆菌%白细胞介素 8%白细胞介素 10%C - 反应蛋白
胃炎%幽門螺桿菌%白細胞介素 8%白細胞介素 10%C - 反應蛋白
위염%유문라간균%백세포개소 8%백세포개소 10%C - 반응단백
Gastritis%Helicobacter pylori%Interleukin - 8%Interleukin - 10%C - reactive protein
目的：探讨幽门螺杆菌（Hp）阳性相关的胃炎患者血清白介素8（IL -8）、白介素10（IL -10）和 C 反应蛋白（CRP）的水平及临床意义。方法选择65例 Hp 阳性相关的胃炎患者作为研究对象，同时纳入30例同期体检健康人员作为对照组，采用酶联免疫吸附（ELISA）法检测两组血清 IL -8、IL -10和 CRP 的浓度。观察 Hp 阳性活动期与非活动期患者上述指标的差异，抗 Hp 治疗前后上述指标的差异。结果 Hp 阳性胃炎患者血清 IL -8、IL -10和 CRP 的水平分别高于对照组（均 P <0.05）；且 Hp 阳性活动期胃炎患者血清 IL -8、IL -10和 CRP 的水平分别高于 Hp 阳性非活动期胃炎患者（均 P <0.05）；采取 Hp 根除治疗后患者血清 IL -8、IL -10和 CRP 的水平下降，明显低于治疗前（均 P <0.05）。结论细胞因子 IL -8、IL -10和 CRP 水平的升高与胃黏膜 Hp 感染密切相关，可作为活动期胃炎及治疗效果的判断指标之一。
目的：探討幽門螺桿菌（Hp）暘性相關的胃炎患者血清白介素8（IL -8）、白介素10（IL -10）和 C 反應蛋白（CRP）的水平及臨床意義。方法選擇65例 Hp 暘性相關的胃炎患者作為研究對象，同時納入30例同期體檢健康人員作為對照組，採用酶聯免疫吸附（ELISA）法檢測兩組血清 IL -8、IL -10和 CRP 的濃度。觀察 Hp 暘性活動期與非活動期患者上述指標的差異，抗 Hp 治療前後上述指標的差異。結果 Hp 暘性胃炎患者血清 IL -8、IL -10和 CRP 的水平分彆高于對照組（均 P <0.05）；且 Hp 暘性活動期胃炎患者血清 IL -8、IL -10和 CRP 的水平分彆高于 Hp 暘性非活動期胃炎患者（均 P <0.05）；採取 Hp 根除治療後患者血清 IL -8、IL -10和 CRP 的水平下降，明顯低于治療前（均 P <0.05）。結論細胞因子 IL -8、IL -10和 CRP 水平的升高與胃黏膜 Hp 感染密切相關，可作為活動期胃炎及治療效果的判斷指標之一。
목적：탐토유문라간균（Hp）양성상관적위염환자혈청백개소8（IL -8）、백개소10（IL -10）화 C 반응단백（CRP）적수평급림상의의。방법선택65례 Hp 양성상관적위염환자작위연구대상，동시납입30례동기체검건강인원작위대조조，채용매련면역흡부（ELISA）법검측량조혈청 IL -8、IL -10화 CRP 적농도。관찰 Hp 양성활동기여비활동기환자상술지표적차이，항 Hp 치료전후상술지표적차이。결과 Hp 양성위염환자혈청 IL -8、IL -10화 CRP 적수평분별고우대조조（균 P <0.05）；차 Hp 양성활동기위염환자혈청 IL -8、IL -10화 CRP 적수평분별고우 Hp 양성비활동기위염환자（균 P <0.05）；채취 Hp 근제치료후환자혈청 IL -8、IL -10화 CRP 적수평하강，명현저우치료전（균 P <0.05）。결론세포인자 IL -8、IL -10화 CRP 수평적승고여위점막 Hp 감염밀절상관，가작위활동기위염급치료효과적판단지표지일。
Objective To explore the clinical significance of serum levels of IL - 8,IL - 10 and CRP in patients with Hp positive gastri-tis. Methods A total of 65 patients with Hp positive gastritis and 30 healthy medical personnel at the same period as control group were selected for this study,the serum levels of IL - 6,IL - 8 and TNF - α were measured by ELISA,and the relationship between their results with Hp infec-tion had been studied. Results The serum levels of IL - 8,IL - 10 and CRP in patients of observation group were higher than those of control group(all P < 0. 05);serum levels of IL - 8,IL - 10 and CRP in patients with active gastritis were higher than those of patients with non - active gastritis but Hp - positive(all P < 0. 05);serum levels of IL - 8,IL - 10 and CRP were decreased after taking Hp eradication therapy(all P <0. 05). Conclusion The elevation of serum levels of IL - 8,IL - 10 and CRP is associated with Hp infection of gastric mucosa,thus it can pro-vide a theoretical basis for diagnosis of active stage of gastritis and it may be served as an indicator for therapeutic efficacy of treatment.
