临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
2期
122-125
,共4页
妊娠期糖尿病%门冬胰岛素%子代%心脏结构%心功能
妊娠期糖尿病%門鼕胰島素%子代%心髒結構%心功能
임신기당뇨병%문동이도소%자대%심장결구%심공능
Gestational diabetes%Insulin aspart%Offspring%Cardiac structure%Cardiac function
目的：探讨门冬胰岛素对妊娠期糖尿病（GDM）的作用及对子代心脏结构和功能的影响。方法选择GDM 孕妇48例，随机分为两组，研究组24例采用门冬胰岛素治疗；对照组24例采用生物合成的人胰岛素，随访两组疗效及母儿结局，并随访两组子代心脏彩超各项参数结果，以正常孕妇（正常组）24例的子代作为正常组对照。结果研究组血糖达标时间明显短于对照组，胰岛素用量也显著低于对照组（ P 均<0.05）。研究组与对照组的主要母儿结局均无统计学差异（ P 均﹥0.05）。研究组子代在左室收缩期末期容积、二尖瓣 E/ A 峰比值、左室 Tei 指数与对照组有统计学差异（ P 均<0.05），其值更接近于正常组。结论门冬胰岛素起效快、降血糖效果好，其治疗后的妊娠期糖尿病患者的1岁婴儿的心脏结构与功能更接近正常孕妇的子代，值得推广。
目的：探討門鼕胰島素對妊娠期糖尿病（GDM）的作用及對子代心髒結構和功能的影響。方法選擇GDM 孕婦48例，隨機分為兩組，研究組24例採用門鼕胰島素治療；對照組24例採用生物閤成的人胰島素，隨訪兩組療效及母兒結跼，併隨訪兩組子代心髒綵超各項參數結果，以正常孕婦（正常組）24例的子代作為正常組對照。結果研究組血糖達標時間明顯短于對照組，胰島素用量也顯著低于對照組（ P 均<0.05）。研究組與對照組的主要母兒結跼均無統計學差異（ P 均﹥0.05）。研究組子代在左室收縮期末期容積、二尖瓣 E/ A 峰比值、左室 Tei 指數與對照組有統計學差異（ P 均<0.05），其值更接近于正常組。結論門鼕胰島素起效快、降血糖效果好，其治療後的妊娠期糖尿病患者的1歲嬰兒的心髒結構與功能更接近正常孕婦的子代，值得推廣。
목적：탐토문동이도소대임신기당뇨병（GDM）적작용급대자대심장결구화공능적영향。방법선택GDM 잉부48례，수궤분위량조，연구조24례채용문동이도소치료；대조조24례채용생물합성적인이도소，수방량조료효급모인결국，병수방량조자대심장채초각항삼수결과，이정상잉부（정상조）24례적자대작위정상조대조。결과연구조혈당체표시간명현단우대조조，이도소용량야현저저우대조조（ P 균<0.05）。연구조여대조조적주요모인결국균무통계학차이（ P 균﹥0.05）。연구조자대재좌실수축기말기용적、이첨판 E/ A 봉비치、좌실 Tei 지수여대조조유통계학차이（ P 균<0.05），기치경접근우정상조。결론문동이도소기효쾌、강혈당효과호，기치료후적임신기당뇨병환자적1세영인적심장결구여공능경접근정상잉부적자대，치득추엄。
Objective To explore the effect of insulin aspart in treatment of patients with gestational diabetes(GDM)and its influence on cardiac function of their offspring. Methods A total of 48 pregnant women in this hospital were collected,24 cases of these pregnant women with GDM treated by insulin aspart were allocated in study group,and 24 pregnant women with GDM using biosynthetic human insulin were composed of control group. The efficacy and outcome were followed - up in these two groups. Echocardiographic parameters of patients in two groups were fol-lowed - up,and 24 cases of normal offspring were collected as normal group. Results The duration for control of blood level of glucose in study group was significantly shorter than that of control group. The amount of insulin was also significantly less than that of control group( P < 0. 05). Main obstetric outcomes between study group and control group were not statistically different( P ﹥ 0. 05). Left ventricular systolic volume,mitral E / A peak ratio,left ventricular Tei index were significantly different between study group and control group( P < 0. 05),and its value was closer to that of normal group. Conclusion Hypoglycemic effect of insulin aspart was more rapid. Cardiac construction in offspring of patients with GDM and their functional indicators were closer to those of offspring of normal pregnant women,and therefore it is worthy to be widely applied.
