CAJ | 학술논문

目的：探讨复方丹参注射液联合头孢哌酮舒巴坦钠治疗慢性肾盂肾炎（ CPN）的临床疗效及对患者血清转化生子因子β1（TFG -β1）的影响。方法110例符合纳入标准的 CPN 患者随机分为两组。每组各55例。对照组给予头孢哌酮舒巴坦钠治疗，观察组在对照组的基础上联合应用复方丹参注射液治疗，观察比较两组患者临床疗效、复发率、肾功能、血清 TGF -β1水平及不良反应发生情况。结果观察组的总有效率和复发率分别为92.7％和1.8％，对照组的分别为78.2％和14.5％，与对照组相比，观察组的总有效率明显增高，而复发率明显降低，差异有统计学意义（ P均<0.05）。治疗后，观察组肾功能指标血肌酐（Scr）、尿素氮（BUN）、尿微量白蛋白及血清 TGF -β1水平较对照组均明显下降，差异有统计学意义（ P 均<0.05）。观察组的不良反应总发生率为9.1％，对照组为16.4％，两组不良反应发生率无统计学差异（ P ﹥0.05）。结论复方丹参注射液联合头孢哌酮舒巴坦钠治疗治疗 CPN 疗效可靠，可以有效提高治疗有效率，减少疾病复发，并明显改善肾功能，延缓肾脏纤维化，且不良反应少，值得临床上进一步研究。
목적：탐토복방단삼주사액연합두포고동서파탄납치료만성신우신염（ CPN）적림상료효급대환자혈청전화생자인자β1（TFG -β1）적영향。방법110례부합납입표준적 CPN 환자수궤분위량조。매조각55례。대조조급여두포고동서파탄납치료，관찰조재대조조적기출상연합응용복방단삼주사액치료，관찰비교량조환자림상료효、복발솔、신공능、혈청 TGF -β1수평급불량반응발생정황。결과관찰조적총유효솔화복발솔분별위92.7％화1.8％，대조조적분별위78.2％화14.5％，여대조조상비，관찰조적총유효솔명현증고，이복발솔명현강저，차이유통계학의의（ P균<0.05）。치료후，관찰조신공능지표혈기항（Scr）、뇨소담（BUN）、뇨미량백단백급혈청 TGF -β1수평교대조조균명현하강，차이유통계학의의（ P 균<0.05）。관찰조적불량반응총발생솔위9.1％，대조조위16.4％，량조불량반응발생솔무통계학차이（ P ﹥0.05）。결론복방단삼주사액연합두포고동서파탄납치료치료 CPN 료효가고，가이유효제고치료유효솔，감소질병복발，병명현개선신공능，연완신장섬유화，차불량반응소，치득림상상진일보연구。
Objective To investigate the clinical effect of compound danshen injection in combination with cefoperazone sulbactam sodium and its effects on serum transforming growth factor beta 1(TGF - β1)in treating patients with chronic pyelonephritis(CPN). Methods 110 ca-ses of CPN meeting the inclusion criteria were randomly divided into 2 groups equally. The control group was treated with cefoperazone sulbactam sodium and the observation group was treated with compound danshen injection in combination with cefoperazone sulbactam sodium. Then,the cur-ative efficacy,recurrence rate,renal function,serum TGF - β1 and adverse reactions were observed and compared. Results The observation group had a total therapeutic efficiency ratio of 92. 7% and a recurrence rate of 1. 8% ,which was respectively statistically higher and lower than that of 78. 2% and 14. 5% in the control group(both P < 0. 05). Compared with the control group,indices reflecting renal function of Scr, BUN,urinary albumin and serum TGF - β1 in the observation group were statistically lower after the treatment(all P < 0. 05). As to adverse re-action,the two groups were statistically same with the occurrence rate of 9. 1% vs 16. 4%( P ﹥ 0. 05). Conclusion Combined treatment of danshen compound injection in combination with cefoperazone sulbactam sodium for CPN was effective,which could increase the therapeutic effi-ciency ratio,reduce recurrence rate,significantly improve renal function,and delay renal fibrosis with little adverse reactions.