临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
2期
106-108
,共3页
胸腺瘤%WHO 病理分型%重症肌无力%临床分期%手术方式%预后
胸腺瘤%WHO 病理分型%重癥肌無力%臨床分期%手術方式%預後
흉선류%WHO 병리분형%중증기무력%림상분기%수술방식%예후
Thymoma%WHO pathological type%Myasthenia gravis%Clinical stage%Surgical method%Prognosis
目的：探讨胸腺瘤最新世界卫生组织（WHO）病理分型与重症肌无力（MG）发生率和临床分期的关系及其对患者预后的影响。方法收集2009年10月至2014年10月行胸腺瘤根治手术的85例患者临床资料，采用最新WHO 病理分型及传统 Masaoka 临床分期对患者进行分类，患者均行手术治疗，观察患者 MG 发生率及手术预后情况。结果 WHO 病理分型中 A 型与 AB 型主要为良性病例，B 型、C 型以恶性病例为主。B2型更容易发生 MG。WHO 病理分型与 Masaoka 临床分型具有显著相关性（ P <0.05）。经手术治疗患者治愈42例，缓解28例，进展8例，死亡7例。胸腺瘤手术方式及病理分期是影响预后的主要因素。结论最新 WHO 病理分型能有效区分胸腺瘤良、恶性，结合Masaoka 临床分期对患者预后有指导意义。临床分期及手术对患者预后影响较大，治疗原则应根据患者良、恶性情况，采用合适的手术方式并辅以放疗、化疗，以提高治疗效果。
目的：探討胸腺瘤最新世界衛生組織（WHO）病理分型與重癥肌無力（MG）髮生率和臨床分期的關繫及其對患者預後的影響。方法收集2009年10月至2014年10月行胸腺瘤根治手術的85例患者臨床資料，採用最新WHO 病理分型及傳統 Masaoka 臨床分期對患者進行分類，患者均行手術治療，觀察患者 MG 髮生率及手術預後情況。結果 WHO 病理分型中 A 型與 AB 型主要為良性病例，B 型、C 型以噁性病例為主。B2型更容易髮生 MG。WHO 病理分型與 Masaoka 臨床分型具有顯著相關性（ P <0.05）。經手術治療患者治愈42例，緩解28例，進展8例，死亡7例。胸腺瘤手術方式及病理分期是影響預後的主要因素。結論最新 WHO 病理分型能有效區分胸腺瘤良、噁性，結閤Masaoka 臨床分期對患者預後有指導意義。臨床分期及手術對患者預後影響較大，治療原則應根據患者良、噁性情況，採用閤適的手術方式併輔以放療、化療，以提高治療效果。
목적：탐토흉선류최신세계위생조직（WHO）병리분형여중증기무력（MG）발생솔화림상분기적관계급기대환자예후적영향。방법수집2009년10월지2014년10월행흉선류근치수술적85례환자림상자료，채용최신WHO 병리분형급전통 Masaoka 림상분기대환자진행분류，환자균행수술치료，관찰환자 MG 발생솔급수술예후정황。결과 WHO 병리분형중 A 형여 AB 형주요위량성병례，B 형、C 형이악성병례위주。B2형경용역발생 MG。WHO 병리분형여 Masaoka 림상분형구유현저상관성（ P <0.05）。경수술치료환자치유42례，완해28례，진전8례，사망7례。흉선류수술방식급병리분기시영향예후적주요인소。결론최신 WHO 병리분형능유효구분흉선류량、악성，결합Masaoka 림상분기대환자예후유지도의의。림상분기급수술대환자예후영향교대，치료원칙응근거환자량、악성정황，채용합괄적수술방식병보이방료、화료，이제고치료효과。
Objective To explore the relationship of latest WHO pathological classification of thymoma with clinical stage and myasthenia gravis(MG). Methods The clinical data of 85 patients who received radical resection of thymoma from October 2009 to October 2014 were col-lected. The patients were classified according to the latest WHO pathological type classification and traditional Masaoka clinical stage classification respectively. The incidence of MG was observed. Results WHO pathological type A and AB thymomas were mainly benign cases,type B and C thymomas were mainly malignant cases. The incidence of MG in type B2 thymoma was higher. WHO pathological type and Masaoka clinical stage showed a significant correlation( P < 0. 05). After surgery,42 patients were cured,28 had remission,8 had progression and 7 died. Surgical method and pathological type were the major factors relevant to the prognosis. Conclusion The latest WHO pathological classification of thymoma can effectively distinguish benign from malignant thymoma;it is of significance for predicting the prognosis of the patients when combined with Masaoka clinical stage classification. The patients should be treated with appropriate surgical method and supplemented with radiotherapy and chemotherapy in order to improve the therapeutic effect.
