中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2015年
2期
68-70
,共3页
汤轶波%朱春燕%袁伟畅%张赛%张林朋%张玮%牟天龙%王旭%杨晓敏%何雪飞%潘彦舒
湯軼波%硃春燕%袁偉暢%張賽%張林朋%張瑋%牟天龍%王旭%楊曉敏%何雪飛%潘彥舒
탕질파%주춘연%원위창%장새%장림붕%장위%모천룡%왕욱%양효민%하설비%반언서
复方当归注射液%缺血性脑损伤%神经功能%脑梗死体积%丙二醛%大鼠
複方噹歸註射液%缺血性腦損傷%神經功能%腦梗死體積%丙二醛%大鼠
복방당귀주사액%결혈성뇌손상%신경공능%뇌경사체적%병이철%대서
compound angelica injection%cerebral ischemia injury%neurologic function%volume of cerebral infarction%MDA%rats
目的:观察大鼠局灶性脑缺血损伤后神经功能、脑梗死体积、脂质过氧化的变化及复方当归注射液的干预作用。方法以线栓法构建SD大鼠大脑中动脉栓塞致局灶性脑缺血损伤模型,随机分为假手术组、模型组、复方当归注射液组(药物组)和阳性对照组。造模后1 h,假手术组和模型组予生理盐水腹腔注射,药物组和阳性对照组分别给予复方当归注射液和依达拉奉注射液腹腔注射,连续7 d,通过神经行为学评分判断大鼠神经功能变化,四氮唑红染色方法测定脑组织梗死体积,硫代巴比妥酸方法检测缺血侧脑组织中丙二醛(MDA)含量。结果脑缺血7 d后,药物组脑梗死体积比及神经功能指标均较模型组显著改善(P<0.05),MDA含量较模型组有一定下降趋势。结论复方当归注射液能显著改善局灶性脑缺血大鼠的神经行为学功能、减小脑梗死体积,并可能有减轻脂质过氧化的作用。
目的:觀察大鼠跼竈性腦缺血損傷後神經功能、腦梗死體積、脂質過氧化的變化及複方噹歸註射液的榦預作用。方法以線栓法構建SD大鼠大腦中動脈栓塞緻跼竈性腦缺血損傷模型,隨機分為假手術組、模型組、複方噹歸註射液組(藥物組)和暘性對照組。造模後1 h,假手術組和模型組予生理鹽水腹腔註射,藥物組和暘性對照組分彆給予複方噹歸註射液和依達拉奉註射液腹腔註射,連續7 d,通過神經行為學評分判斷大鼠神經功能變化,四氮唑紅染色方法測定腦組織梗死體積,硫代巴比妥痠方法檢測缺血側腦組織中丙二醛(MDA)含量。結果腦缺血7 d後,藥物組腦梗死體積比及神經功能指標均較模型組顯著改善(P<0.05),MDA含量較模型組有一定下降趨勢。結論複方噹歸註射液能顯著改善跼竈性腦缺血大鼠的神經行為學功能、減小腦梗死體積,併可能有減輕脂質過氧化的作用。
목적:관찰대서국조성뇌결혈손상후신경공능、뇌경사체적、지질과양화적변화급복방당귀주사액적간예작용。방법이선전법구건SD대서대뇌중동맥전새치국조성뇌결혈손상모형,수궤분위가수술조、모형조、복방당귀주사액조(약물조)화양성대조조。조모후1 h,가수술조화모형조여생리염수복강주사,약물조화양성대조조분별급여복방당귀주사액화의체랍봉주사액복강주사,련속7 d,통과신경행위학평분판단대서신경공능변화,사담서홍염색방법측정뇌조직경사체적,류대파비타산방법검측결혈측뇌조직중병이철(MDA)함량。결과뇌결혈7 d후,약물조뇌경사체적비급신경공능지표균교모형조현저개선(P<0.05),MDA함량교모형조유일정하강추세。결론복방당귀주사액능현저개선국조성뇌결혈대서적신경행위학공능、감소뇌경사체적,병가능유감경지질과양화적작용。
Objective To investigate neurological function, volume of cerebral infarction, changes of lipid peroxidation, and the intervention effect of compound angelica injection (CAI) on rats with focal cerebral ischemia injury. Methods Models of rat with cerebral ischemia were reproduced by middle cerebral artery occlusion (MCAO). All animals were randomly divided into sham-operation group, model group, CAI group, and edaravone group. 1 hour after the models were established, rats in the sham-operation group and model group received intraperitoneal injection with normal saline, while rats in CAI group and edaravone group received intraperitoneal injection with relevant medicine for continuing 7 days. Volume of cerebral infarction was detected by Tetrazole staining method, neurologic function were detected by neuroethology, and concentration of MDA in brain tissue was also detected. Results After 7-day cerebral ischemia, compared with the model group, volume of cerebral infarction in CAI group was significantly reduced (P<0.05), and the concentration of MDA was a little lower. Conclusion CAI has significant protective effects which can significantly improve neurological function, reduce volume of cerebral infarction, and alleviate the effects of lipid peroxidation of rats with focal cerebral ischemia injury.