CAJ | 학술논문

目的：观察十味龙胆花胶囊联合西药治疗轻度慢性阻塞性肺疾病急性加重(痰热壅肺证)患者的临床疗效。方法选择符合轻度慢性阻塞性肺疾病急性加重的西医诊断标准且中医辨证为痰热壅肺证患者192例,随机分为观察组和对照组各96例。观察组应用十味龙胆花胶囊及西药常规治疗,对照组应用西药常规治疗,疗程10 d,测定并比较治疗前后中医证候积分、主要症状评分和肺功能变化。结果疗程结束后,观察组14例失访,对照组15例失访。观察组总有效率为80.29%(66/82),对照组为56.79%(46/81),观察组优于对照组(P＜0.05)；观察组改善患者咳嗽严重程度、频率、咯痰量的疗效优于对照组(P＜0.05)；2组患者在喘息症状、肺功能方面均有改善,疗效相当。结论十味龙胆花胶囊联合西药常规治疗轻度慢性阻塞性肺疾病急性加重(痰热壅肺证)患者的疗效及在改善咳嗽、咯痰等临床症状方面优于单纯西药常规治疗。
목적：관찰십미룡담화효낭연합서약치료경도만성조새성폐질병급성가중(담열옹폐증)환자적림상료효。방법선택부합경도만성조새성폐질병급성가중적서의진단표준차중의변증위담열옹폐증환자192례,수궤분위관찰조화대조조각96례。관찰조응용십미룡담화효낭급서약상규치료,대조조응용서약상규치료,료정10 d,측정병비교치료전후중의증후적분、주요증상평분화폐공능변화。결과료정결속후,관찰조14례실방,대조조15례실방。관찰조총유효솔위80.29%(66/82),대조조위56.79%(46/81),관찰조우우대조조(P＜0.05)；관찰조개선환자해수엄중정도、빈솔、각담량적료효우우대조조(P＜0.05)；2조환자재천식증상、폐공능방면균유개선,료효상당。결론십미룡담화효낭연합서약상규치료경도만성조새성폐질병급성가중(담열옹폐증)환자적료효급재개선해수、각담등림상증상방면우우단순서약상규치료。
Objective To observe the clinical efficacy of Shiwei Longdanhua Capsule combined with western medicine on patients with mild acute exacerbation of chronic obstructive pulmonary disease (COPD) with phlegm-heat obstructing lung syndrome. Methods Totally 192 cases of COPD with mild acute exacerbation (phlegm-heat obstructing lung syndrome) were recruited. They were randomly divided into the treatment group (96 cases) and the control group (96 cases). Patients in the control group were treated in line with the regular Western treatment, while patients in the treatment group were additionally treated by Shiwei Longdanhua Capsule. After 10-day treatment, the changes of TCM syndrome score, symptom integral and the lung function before and after treatment were compared. Results After treatment, 14 patients withdrew from the treatment group and 15 patients withdrew from the control group. The total efficiency rate of TCM syndrome was 80.49% (66/82) in the treatment group, while it was 56.79% (46/81) in the control group, with statistical difference between the two groups (P<0.05). The severity and frequency of cough and expectoration of the treatment group were better than the control group (P<0.05). The breathing symptom and pulmonary function of patients in the two groups improved, with similar efficacy. Conclusion The efficiency of Shiwei Longdanhua Capsule combined with Western medicine in the treatment of acute exacerbation of COPD is superior to that of simple Western medicine treatment, especially in terms of relieving cough and expectoration.