中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2015年
2期
83-85
,共3页
王锐%闫丽莉%谢国梁%杨婧%刘焱南%王艳宏%李伟男%管庆霞%李永吉
王銳%閆麗莉%謝國樑%楊婧%劉焱南%王豔宏%李偉男%管慶霞%李永吉
왕예%염려리%사국량%양청%류염남%왕염굉%리위남%관경하%리영길
蛇床子素%包合工艺%羟丙基-β-环糊精%二次正交旋转组合设计
蛇床子素%包閤工藝%羥丙基-β-環糊精%二次正交鏇轉組閤設計
사상자소%포합공예%간병기-β-배호정%이차정교선전조합설계
osthol%preparation process%hydroxypropyl-β-cyclodextrin%orthogonal and rotational combination design
目的：确定蛇床子素羟丙基-β-环糊精包合工艺。方法采用不饱和水溶液-冷冻干燥法制备包合物,以二次正交旋转组合设计法设计羟丙基-β-环糊精包合工艺,采用高效液相色谱法测定包封率。结果确定最佳包合工艺为：羟丙基-β-环糊精与药物比例为4.5∶1,电动搅拌机35℃,恒温水浴搅拌210 min,进行包封。结论所确定的制备工艺合理可行,具有良好的开发应用前景。
目的：確定蛇床子素羥丙基-β-環糊精包閤工藝。方法採用不飽和水溶液-冷凍榦燥法製備包閤物,以二次正交鏇轉組閤設計法設計羥丙基-β-環糊精包閤工藝,採用高效液相色譜法測定包封率。結果確定最佳包閤工藝為：羥丙基-β-環糊精與藥物比例為4.5∶1,電動攪拌機35℃,恆溫水浴攪拌210 min,進行包封。結論所確定的製備工藝閤理可行,具有良好的開髮應用前景。
목적：학정사상자소간병기-β-배호정포합공예。방법채용불포화수용액-냉동간조법제비포합물,이이차정교선전조합설계법설계간병기-β-배호정포합공예,채용고효액상색보법측정포봉솔。결과학정최가포합공예위：간병기-β-배호정여약물비례위4.5∶1,전동교반궤35℃,항온수욕교반210 min,진행포봉。결론소학정적제비공예합리가행,구유량호적개발응용전경。
Objective To study the process of hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion techniques for osthol. Methods The inclusion complex of osthol and HP-β-CD was prepared by unsaturated water solution and freeze-drying technique. Inclusion techniques were selected by screening on quadratic orthogonal rotation combination design method, and the entrapment efficiency was identified by HPLC. Results The optimal technical conditions were as follows:the ratio of HP-β-CD and drug was 4.5∶1;temperature for electric mixer was 35 ℃;the stirring time for thermostatic waterbath was 210 min. Conclusion This method is reasonable and it may have a prosperous future of development and application.
