CAJ | 학술논문

目的：探讨慢性丙型肝炎采用重组人干扰素α-2b治疗的临床效果。方法选取慢性丙型肝炎100例为研究对象,均为我院2009年4月~2014年4月收治的患者,随机分为两组,比较重组人干扰素α-2b治疗﹙观察组, n=50)与普通干扰素-2b治疗﹙对照组,n=50)的临床治疗效果。结果治疗后,两组均有纳差恶心、发热恶寒、身痛乏力、咯痰咳嗽、鼻塞咽痛等症状,对症处理均消失。两组患者少数有中性粒细胞及白细胞下降,取升白药物应用,恢复正常。观察组脱发1例,对照组2例,药物停用后好转。观察组治疗12周、24周、治疗后24周ALT复常率均高于对照组﹙P<0.05)。结论慢性丙型肝炎采用重组人干扰素α-2b治疗可显著改善预后,提高生存质量。
목적：탐토만성병형간염채용중조인간우소α-2b치료적림상효과。방법선취만성병형간염100례위연구대상,균위아원2009년4월~2014년4월수치적환자,수궤분위량조,비교중조인간우소α-2b치료﹙관찰조, n=50)여보통간우소-2b치료﹙대조조,n=50)적림상치료효과。결과치료후,량조균유납차악심、발열악한、신통핍력、각담해수、비새인통등증상,대증처리균소실。량조환자소수유중성립세포급백세포하강,취승백약물응용,회복정상。관찰조탈발1례,대조조2례,약물정용후호전。관찰조치료12주、24주、치료후24주ALT복상솔균고우대조조﹙P<0.05)。결론만성병형간염채용중조인간우소α-2b치료가현저개선예후,제고생존질량。
Objective To explore the clinic effect of recombinant human interferon α-2b in treatment of chronic hep-atitis C. Methods A total of 100 cases of chronic hepatitis C in our hospital from April 2009 to April 2014 were divided into recombinant human interferon α-2b treatment ﹙observation group,n=50) with ordinary -2b interferon treatment﹙control group, n=50),and the effects were compared. Results After treatment,both groups anorexia, nausea, fever, chills,body pain, fatigue,cough cough,nasal congestion,sore throat and other symptoms, symptomatic treatment, were all disappeared. Two groups of patients had few neutrophils and leukopenia, take up the white drug applications, re-turned to normal,alopecia:observation group 1 case, group 2 cases,the drug improved after the closure. ALT normaliza-tion rates of observation group treatment for 12 weeks,24 weeks and 24 weeks were higher than control group, the dif-ference was statistically significant after treatment ﹙P<0.05). Conclusion Chronic hepatitis C using recombinant hu-man interferonα-2b therapy,can significantly improve the prognosis, protect the quality of life of patients.