CAJ | 학술논문

目的：探讨痰热清注射液联合头孢哌酮舒巴坦钠针对慢性支气管炎急性发作期C反应蛋白的影响。方法选取2013年6月~2014年6月来我院治疗的100例慢性支气管炎急性发作期患者为研究对象,全部入选病例随机分为观察组和对照组,每组50例,两组均予以止咳、化痰、平喘及吸氧等对症治疗,观察组同时应用痰热清注射液20 mL加入注射用5%葡萄糖注射液250 mL中静脉点滴,1次/d；头孢哌酮舒巴坦钠针3.0 g﹙少部分患者应用2.0 g)加入注射用生理盐水100 mL中静脉点滴,1次/12 h。疗程10 d。比较两组的临床疗效及两组患者治疗后痰液消失时间、咳嗽消失时间、肺部湿啰音消失时间和PaO2、PaCO2的变化及两组患者治疗前后CRP水平的变化。结果两组治疗后的总有效率分别为94.0%、80.0%,差异具有统计学意义﹙P<0.05)。观察组患者的痰液消失时间、咳嗽消失时间、肺部湿啰音消失时间均短于对照组,差异具有统计学意义﹙P<0.05)。观察组患者治疗后的PaO2明显高于对照组,而PaCO2显著低于对照组,差异具有统计学意义﹙P<0.05)。观察组患者的CRP水平较对照组降低更显著,差异具有统计学意义﹙P<0.05)。结论痰热清注射液联合头孢哌酮舒巴坦钠针治疗慢性支气管炎急性发作期可提高疗效,降低CRP水平,明显改善患者的临床症状、体征,值得推广和应用。
목적：탐토담열청주사액연합두포고동서파탄납침대만성지기관염급성발작기C반응단백적영향。방법선취2013년6월~2014년6월래아원치료적100례만성지기관염급성발작기환자위연구대상,전부입선병례수궤분위관찰조화대조조,매조50례,량조균여이지해、화담、평천급흡양등대증치료,관찰조동시응용담열청주사액20 mL가입주사용5%포도당주사액250 mL중정맥점적,1차/d；두포고동서파탄납침3.0 g﹙소부분환자응용2.0 g)가입주사용생리염수100 mL중정맥점적,1차/12 h。료정10 d。비교량조적림상료효급량조환자치료후담액소실시간、해수소실시간、폐부습라음소실시간화PaO2、PaCO2적변화급량조환자치료전후CRP수평적변화。결과량조치료후적총유효솔분별위94.0%、80.0%,차이구유통계학의의﹙P<0.05)。관찰조환자적담액소실시간、해수소실시간、폐부습라음소실시간균단우대조조,차이구유통계학의의﹙P<0.05)。관찰조환자치료후적PaO2명현고우대조조,이PaCO2현저저우대조조,차이구유통계학의의﹙P<0.05)。관찰조환자적CRP수평교대조조강저경현저,차이구유통계학의의﹙P<0.05)。결론담열청주사액연합두포고동서파탄납침치료만성지기관염급성발작기가제고료효,강저CRP수평,명현개선환자적림상증상、체정,치득추엄화응용。
Objective To explore the effect of Tanreqing injection combined with cefoperazone sodium and Sulbactam sodium in threatment of acute exacerbations of chronic bronchitis,and to explore the impact on C reactive protein. Methods From 2013 June to 2014 June in our hospital,100 cases of patients with acute exacerbation of chronic bron-chitis were selected as the object of study, all the patients were randomly divided into observation group and control group, 50 cases in each group, two groups were treated with cough, phlegm, relieving asthma and oxygen and other symptomatic treatment, while the observation group was treated with Tanreqing injection 20 mL into injection and in-travenous drip for 5% Glucose injection in 250 mL, once per day. Cefoperazone sodium and sulbactam sodium needle 3 g﹙a small number of patients with application of 2 g) with injection of saline 100 mL intravenous drip, 1 times/12 h. The course of treatment was 10 days. The clinical efficacy of the two groups and two groups of patients after sputum cough disappeared time change, vanishing lung wet rales disappearance time and PaO2, PaCO2, and changes of CRP before and after treatment in two groups of patients were compared. Results After treatment, the total effective rate in the observation group and the control was 94.0%, 80.0%, the effects of two groups were compared, the difference was statistically significant﹙P<0.05). The observation group patients’s sputum, cough disappeared time, the disappearance time of pulmonary rales disappearance time were faster than the control group, the difference was statistically signifi-cant ﹙P<0.05). PaO2 of observation group after treatment was significantly higher than the control group, while PaCO2 was significantly lower than the control group, the difference was statistically significant﹙P<0.05). The CRP level of ob-servation group decreased more significantly than the control group, the difference was statistically significant﹙P<0.05). Conclusion The therapeutic effect of Tanreqing injection combined with cefoperazone Sulbactam sodium injection in treatment of chronic bronchitis in acute attack period can improve the curative effect, decrease the level of CRP, im-prove the patient's clinical symptoms, signs, and is worthy of promotion and application.