包头医学院学报
包頭醫學院學報
포두의학원학보
JOURNAL OF BAOTOU MEDICAL COLLEGE
2015年
1期
3-6
,共4页
贲门癌%CDX2%Villin%免疫组化
賁門癌%CDX2%Villin%免疫組化
분문암%CDX2%Villin%면역조화
Cardia carcinoma%CDX2%Villin%Immunohistochemistry
目的：探讨CDX2与Villin在正常贲门组织、癌旁组织及贲门癌组织中的表达及临床意义。方法：收集正常贲门组织28例和贲门癌组织标本80例，应用免疫组化的方法检测CDX2蛋白与Villin蛋白在正常贲门组织、癌旁组织和贲门癌组织中的表达情况，分析CDX2蛋白、Villin蛋白与贲门癌临床病理学特征的关系及临床意义。结果：1．CDX2蛋白在28例正常贲门组织中无表达，在80例贲门癌组织及贲门癌旁组织中的表达率分别为37．5％（30／80）和62．5％（50／80），CDX2蛋白在各组间的表达差异具有统计学意义（P ＜0．01）；Villin蛋白在28例正常贲门组织中无表达，在80例贲门癌组织及癌旁组织中的表达率分别为40．0％（32／80）和60．0％（48／80），组间差异具有统计学意义（P ＜0．01）。2．贲门癌组织中CDX2蛋白与 Villin 蛋白的表达均与性别、年龄、肿瘤大小、TNM分期、浸润程度及淋巴结转移无关（ P ＞0．01），而在高－中分化贲门癌组织中的表达率均高于低分化贲门癌组织中的表达率（P ＜0．01）。结论：1．CDX2蛋白和Villin蛋白可能是贲门癌发生的抑制因素；2．CDX2蛋白和 Villin 蛋白的表达均与贲门癌的分化程度有关，这两种蛋白和贲门癌的恶性程度有一定关系。
目的：探討CDX2與Villin在正常賁門組織、癌徬組織及賁門癌組織中的錶達及臨床意義。方法：收集正常賁門組織28例和賁門癌組織標本80例，應用免疫組化的方法檢測CDX2蛋白與Villin蛋白在正常賁門組織、癌徬組織和賁門癌組織中的錶達情況，分析CDX2蛋白、Villin蛋白與賁門癌臨床病理學特徵的關繫及臨床意義。結果：1．CDX2蛋白在28例正常賁門組織中無錶達，在80例賁門癌組織及賁門癌徬組織中的錶達率分彆為37．5％（30／80）和62．5％（50／80），CDX2蛋白在各組間的錶達差異具有統計學意義（P ＜0．01）；Villin蛋白在28例正常賁門組織中無錶達，在80例賁門癌組織及癌徬組織中的錶達率分彆為40．0％（32／80）和60．0％（48／80），組間差異具有統計學意義（P ＜0．01）。2．賁門癌組織中CDX2蛋白與 Villin 蛋白的錶達均與性彆、年齡、腫瘤大小、TNM分期、浸潤程度及淋巴結轉移無關（ P ＞0．01），而在高－中分化賁門癌組織中的錶達率均高于低分化賁門癌組織中的錶達率（P ＜0．01）。結論：1．CDX2蛋白和Villin蛋白可能是賁門癌髮生的抑製因素；2．CDX2蛋白和 Villin 蛋白的錶達均與賁門癌的分化程度有關，這兩種蛋白和賁門癌的噁性程度有一定關繫。
목적：탐토CDX2여Villin재정상분문조직、암방조직급분문암조직중적표체급림상의의。방법：수집정상분문조직28례화분문암조직표본80례，응용면역조화적방법검측CDX2단백여Villin단백재정상분문조직、암방조직화분문암조직중적표체정황，분석CDX2단백、Villin단백여분문암림상병이학특정적관계급림상의의。결과：1．CDX2단백재28례정상분문조직중무표체，재80례분문암조직급분문암방조직중적표체솔분별위37．5％（30／80）화62．5％（50／80），CDX2단백재각조간적표체차이구유통계학의의（P ＜0．01）；Villin단백재28례정상분문조직중무표체，재80례분문암조직급암방조직중적표체솔분별위40．0％（32／80）화60．0％（48／80），조간차이구유통계학의의（P ＜0．01）。2．분문암조직중CDX2단백여 Villin 단백적표체균여성별、년령、종류대소、TNM분기、침윤정도급림파결전이무관（ P ＞0．01），이재고－중분화분문암조직중적표체솔균고우저분화분문암조직중적표체솔（P ＜0．01）。결론：1．CDX2단백화Villin단백가능시분문암발생적억제인소；2．CDX2단백화 Villin 단백적표체균여분문암적분화정도유관，저량충단백화분문암적악성정도유일정관계。
Objective:To investigate the expression and clinical significance of CDX2 and Villin in the normal cardiac tissue, para cancer and cardia cancer.Methods:Samples of 28 cases of normal gastric cardia tissue and 80 cases of cardiac cancer tissue were collected.Then the expres-sion of CDX2 protein and Villin protein in normal gastric tissue , para cancerous tissues and gastric cardia carcinoma were examined by immunohis-tochemistry ;the pathological relationship between CDX2 protein , Villin protein and gastric cardia carcinoma and its clinical significance were ana-lyzed.Results:1.There was no expression of CDX2 protein in normal gastric tissues of 28 cases.The expression rate was 37.5 % (30/80) and 62.5% (50/80) respectively in the 80 cases of gastric cardia carcinoma and para cancerous tissue.The expression of CDX2 protein in each group was significantly different ( P <0.01).There was no expression of Villin protein in the 28 cases of normal gastric tissue.The expression rate was 40% (32/80) and 60.0 % (48/80) respectively in the 80 cases of gastric cardia carcinoma and para cancerous tissue.The expression of Villin protein in each group was significantly different.( P <0.01).2.The expression of CDX2 protein and Villin protein had nothing to do with gen-der, age, TNM, degree of infiltration and lymph node metastasis in gastric cardia carcinoma ( P >0.01).The expression rate of CDX2 protein and Villin protein in the cardia carcinoma tissue of high -middle differentiation was higher than that of the cardiac cancer tissue of low differentia-tion ( P <0.01).Conclusions:1.CDX2 protein and Villin protein may be the inhibiting factors of cardia carcinoma.2 The expression rates of CDX2 protein and Villin protein are associated with the degree of differentiation of the cardia carcinoma .There is a certain relationship between these two kinds of proteins and the degree of malignant cardia carcinoma .
