中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
3期
119-120
,共2页
糖尿病视网膜病变%脂蛋白(a)%D-二聚体
糖尿病視網膜病變%脂蛋白(a)%D-二聚體
당뇨병시망막병변%지단백(a)%D-이취체
Diabetic retinopathy%Lipoprotein(a)%D-dimer
目的：探讨不同分期糖尿病视网膜病变(DR)患者血清脂蛋白(α)[LP(a)]和D-二聚体(D-D)水平变化及意义。方法：将126例2型糖尿病患者根据眼底检查及眼底荧光造影结果分为3组：糖尿病无视网膜病变期(NDR)、单纯型糖尿病视网膜病变期(SDR)和增殖型糖尿病视网膜病变期(PDR)。另选40例健康者为正常对照(NC)组。测定各组患者及健康者血清 LP(α)和 D-D 水平，同时研究 LP(α)和 D-D 水平的相关性。结果：LP(α)水平：NC 组＜NDR 组＜SDR 组＜PDR 组，各组间比较差异均有统计学意义(P＜0.05)。D-D 水平：NC 组＜NDR 组＜SDR 组＜PDR 组，各组间比较差异均有统计学意义(P＜0.05)。血清LP(α)和D-D的相关性：直线相关分析表明，血清LP(α)和D-D呈正相关(r=0.502，P＜0.01)。结论：联合检测血清 LP(α)和 D-D 水平有助于早期诊断 DR，并判断其严重程度，为临床上通过降低血清LP(α)、D-D水平控制和延缓糖尿病视网膜病变的发展提供依据。
目的：探討不同分期糖尿病視網膜病變(DR)患者血清脂蛋白(α)[LP(a)]和D-二聚體(D-D)水平變化及意義。方法：將126例2型糖尿病患者根據眼底檢查及眼底熒光造影結果分為3組：糖尿病無視網膜病變期(NDR)、單純型糖尿病視網膜病變期(SDR)和增殖型糖尿病視網膜病變期(PDR)。另選40例健康者為正常對照(NC)組。測定各組患者及健康者血清 LP(α)和 D-D 水平，同時研究 LP(α)和 D-D 水平的相關性。結果：LP(α)水平：NC 組＜NDR 組＜SDR 組＜PDR 組，各組間比較差異均有統計學意義(P＜0.05)。D-D 水平：NC 組＜NDR 組＜SDR 組＜PDR 組，各組間比較差異均有統計學意義(P＜0.05)。血清LP(α)和D-D的相關性：直線相關分析錶明，血清LP(α)和D-D呈正相關(r=0.502，P＜0.01)。結論：聯閤檢測血清 LP(α)和 D-D 水平有助于早期診斷 DR，併判斷其嚴重程度，為臨床上通過降低血清LP(α)、D-D水平控製和延緩糖尿病視網膜病變的髮展提供依據。
목적：탐토불동분기당뇨병시망막병변(DR)환자혈청지단백(α)[LP(a)]화D-이취체(D-D)수평변화급의의。방법：장126례2형당뇨병환자근거안저검사급안저형광조영결과분위3조：당뇨병무시망막병변기(NDR)、단순형당뇨병시망막병변기(SDR)화증식형당뇨병시망막병변기(PDR)。령선40례건강자위정상대조(NC)조。측정각조환자급건강자혈청 LP(α)화 D-D 수평，동시연구 LP(α)화 D-D 수평적상관성。결과：LP(α)수평：NC 조＜NDR 조＜SDR 조＜PDR 조，각조간비교차이균유통계학의의(P＜0.05)。D-D 수평：NC 조＜NDR 조＜SDR 조＜PDR 조，각조간비교차이균유통계학의의(P＜0.05)。혈청LP(α)화D-D적상관성：직선상관분석표명，혈청LP(α)화D-D정정상관(r=0.502，P＜0.01)。결론：연합검측혈청 LP(α)화 D-D 수평유조우조기진단 DR，병판단기엄중정도，위림상상통과강저혈청LP(α)、D-D수평공제화연완당뇨병시망막병변적발전제공의거。
Objective:To explore the changes and significances of serum lipoprotein(a) [LP( α)] and D-dimer(D-D) levels of patients with diabetic retinopathy(DR) in different stages.Methods:According to fundus examination and fundus fluorescence angiography results,126 patients with type 2 diabetes were divided into 3 groups:diabetes without retinopathy period(NDR),simple diabetic retinopathy period(SDR) and proliferative type diabetic retinopathy period(PDR).40 healthy persons were selected as the normal control group(NC).The serum LP(α) and D-D levels of patients and healthy persons were detected,and the correlation between the LP(α) and D-D levels were studied.Results:LP(α) levels:NC group<NDR group<SDR group<PDR group,there were statistically significant differences between groups were compared(P<0.05).D-D levels:NC group<NDR group<SDR group<PDR group,there were statistically significant differences between groups were compared(P<0.05).The correlation between serum LP(α) and D-D:linear correlation analysis showed that serum LP(α) and D-D were positively correlated(r=0.502, P<0.01).Conclusion:Combined detection of serum LP(α) and D-D level is helpful to the early diagnosis of DR,and determine its severity.It provides the basis for lowering the serum LP( α) and D-D level to control and delay the development of diabetic retinopathy in clinical.
