CAJ | 학술논문

为了研究麻保沙星在犬皮下给药的生物利用度，将18只犬随机分成2组，按照2 mg／kg分别皮下注射或静脉注射麻保沙星后，采血待检，2周后两组交叉给药后，采血。分别在药物注射后5、10、15、30、45 min ，1、1．5、2，4、6，8、12、24、36、72 h时采集血液。血浆通过高效液相色谱法检测药物浓度，用3P97药代动力学软件进行分析。麻保沙星皮下注射的平均药代动力学参数为：t1／2ka＝0．19±0．08 h ；t1／2ke ＝7．21±1．88 h；tmax ＝0．97±0．29 h ；Cmax ＝1．13±0．17μg／mL ；AUC＝13．13±4．24μg · h／mL ；CL＝0．17±0．05 L／h ；V／F＝1．63±0．24 L／kg。犬皮下注射麻保沙星的绝对生物利用度为66．7％，皮下注射能迅速被吸收且有较高的组织渗透性。
위료연구마보사성재견피하급약적생물이용도，장18지견수궤분성2조，안조2 mg／kg분별피하주사혹정맥주사마보사성후，채혈대검，2주후량조교차급약후，채혈。분별재약물주사후5、10、15、30、45 min ，1、1．5、2，4、6，8、12、24、36、72 h시채집혈액。혈장통과고효액상색보법검측약물농도，용3P97약대동역학연건진행분석。마보사성피하주사적평균약대동역학삼수위：t1／2ka＝0．19±0．08 h ；t1／2ke ＝7．21±1．88 h；tmax ＝0．97±0．29 h ；Cmax ＝1．13±0．17μg／mL ；AUC＝13．13±4．24μg · h／mL ；CL＝0．17±0．05 L／h ；V／F＝1．63±0．24 L／kg。견피하주사마보사성적절대생물이용도위66．7％，피하주사능신속피흡수차유교고적조직삼투성。
In order to study on bioavailability of marbofloxacin after subsutaneous administration in dogs . 18 dogs were divided into two groups randomly ,subcutaneous and intravenous administrated with 2 mg/kg bodyweight of marbofloxacin ,then ,cross administrated after 2 weeks .The plasma was collected at 5 ,10 , 15 ,30 ,45 min ,1 ,1 .5 ,2 ,4 ,6 ,8 ,12 ,24 ,36 ,72 h .Drug concentration in plasma was determined by high performance liquid chromatography and the data were analyzed by 3P97 pharmacokinetics software . Mean pharmacokinetic parameters after subcutaneous administration were the following :t1/2ka = 0 .19 ± 0 .08 h;t1/2ke = 7 .21 ± 1 .88 h ;tmax = 0 .97 ± 0 .29 h ;Cmax = 1 .13 ± 0 .17 μg/mL ;AUC = 13 .13 ± 4 .24 μg · h/mL ;V/F=1 .63 ± 0 .24 L/kg and CL=0 .17 ± 0 .05 L/h .Bioavailability of marbofloxacin was about 66 .7% in dogs after subcutaneous administration ,and Marbofloxacin was rapidly absorbed after subcutaneous administration and good tissue penetration .