CAJ | 학술논문

取健康志愿者外周静脉血并分离血小板，采用随机分组的方式将血小板分成6组。通过检测血小板最大聚集率、膜表面CD62P及PAC-1阳性表达率，探讨不同浓度的牛磺酸(Tau)对苯并芘(BAP)体外诱导血小板聚集活化功能的影响。结果表明，血小板最大聚集率在二磷酸腺苷( ADP)和胶原诱导下各浓度BAP-Tau组与溶剂对照组之间比较差异均有统计学意义(P<0．01)。血小板膜表面CD62P、PAC-1表达率BAP-Tau高浓度组与溶剂对照组比较差异有统计学意义(P<0．01)。不同浓度的Tau均可拮抗BAP致血小板功能损伤的作用，且呈浓度梯度性变化。
취건강지원자외주정맥혈병분리혈소판，채용수궤분조적방식장혈소판분성6조。통과검측혈소판최대취집솔、막표면CD62P급PAC-1양성표체솔，탐토불동농도적우광산(Tau)대분병비(BAP)체외유도혈소판취집활화공능적영향。결과표명，혈소판최대취집솔재이린산선감( ADP)화효원유도하각농도BAP-Tau조여용제대조조지간비교차이균유통계학의의(P<0．01)。혈소판막표면CD62P、PAC-1표체솔BAP-Tau고농도조여용제대조조비교차이유통계학의의(P<0．01)。불동농도적Tau균가길항BAP치혈소판공능손상적작용，차정농도제도성변화。
The peripheral renous blood which were taken from healthy volunteers and platelet was isolated. Platelet samples were randomly divided into six groups. The effects of different concentration of taurine( Tau) on benzo py-rene( BAP) induced platelet aggregation in vitro activation function were investigated by detecting the maximum platelet aggregation rate, the positive expression rates of platelet membrane surface CD62P and PAC-1. The results showed that platelet maximum aggregation rate had significant differences between each concentration of BAP-Tau groups and solvent control group in adenosine diphosphate(ADP) and collagen induced (P<0. 01). The positive expression rates of platelet membrane surface CD62 P and PAC-1 in BAP-Tau high concentration group had signifi-cant differences compared with solvent control group ( P<0. 01 ) . Different concentration of Tau could antagonize platelet function damage induced by BAP with a concentration gradient change.