安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2015年
1期
5-9
,共5页
高尿酸血症%肾损伤%炎症%信号通路
高尿痠血癥%腎損傷%炎癥%信號通路
고뇨산혈증%신손상%염증%신호통로
hyperuricemia%renal injury%inflammation%signaling pathway
高尿酸血症（HUA）长期以来被认为是痛风的致病因子，但近年来大量的流行病学和临床研究表明高尿酸血症在肾损伤的发病和发展中起了重要作用。研究表明还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶、肾素—血管紧张素—醛固酮系统（RAAS）、丝裂原激活蛋白激酶（MAPK）信号、转化生长因子-β（TGF-β）、上皮间质转型等都单独的或共同的参与了肾病的发生和发展过程。目前研究争论的焦点主要集中在尿酸诱导肾损伤中的确切机制，该文主要根据现有的研究成果系统性地总结尿酸在肾损伤中的确切作用及可能的病理生理学分子机制。
高尿痠血癥（HUA）長期以來被認為是痛風的緻病因子，但近年來大量的流行病學和臨床研究錶明高尿痠血癥在腎損傷的髮病和髮展中起瞭重要作用。研究錶明還原型煙酰胺腺嘌呤二覈苷痠燐痠（NADPH）氧化酶、腎素—血管緊張素—醛固酮繫統（RAAS）、絲裂原激活蛋白激酶（MAPK）信號、轉化生長因子-β（TGF-β）、上皮間質轉型等都單獨的或共同的參與瞭腎病的髮生和髮展過程。目前研究爭論的焦點主要集中在尿痠誘導腎損傷中的確切機製，該文主要根據現有的研究成果繫統性地總結尿痠在腎損傷中的確切作用及可能的病理生理學分子機製。
고뇨산혈증（HUA）장기이래피인위시통풍적치병인자，단근년래대량적류행병학화림상연구표명고뇨산혈증재신손상적발병화발전중기료중요작용。연구표명환원형연선알선표령이핵감산린산（NADPH）양화매、신소—혈관긴장소—철고동계통（RAAS）、사렬원격활단백격매（MAPK）신호、전화생장인자-β（TGF-β）、상피간질전형등도단독적혹공동적삼여료신병적발생화발전과정。목전연구쟁론적초점주요집중재뇨산유도신손상중적학절궤제，해문주요근거현유적연구성과계통성지총결뇨산재신손상중적학절작용급가능적병리생이학분자궤제。
Hyperuricemia has long been regarded as the major pathogenic factor in gout.A lot of epidemiological and clinical studies in recent years have accumulated that hyperuricemia may play an important role in the pathogenesis and progression of renal injury.Recent studies suggested nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase),the renin-angiotensin aldosterone system (RAAS),mitogen-activatedproteinkinases (MAPK)signals,transforming growth factor β(TGF-β),phenotypic transition of renal tubu-lar cells,etc.are activated during the course of renal injury and that these pathways individually or collectively play a role in the induc-tion and progression of renal injury.Now,controversy regarding the exact role of hyperuricemia in inducing the renal injury remains to be unfolded,the focus of this review is to systematically summarize the available evidence supporting the exact roles and mechanisms for u-ric acid in the development of renal injury and the potential pathophysiological molecular mechanisms involved.
