贵州农业科学
貴州農業科學
귀주농업과학
GUIZHOU AGRICULTURAL SCIENCES
2015年
1期
108-110
,共3页
陈敏%易文燕%俸婷婷%周英
陳敏%易文燕%俸婷婷%週英
진민%역문연%봉정정%주영
川楝子%正丁醇部位%急性毒性%半数致死量
川楝子%正丁醇部位%急性毒性%半數緻死量
천련자%정정순부위%급성독성%반수치사량
Melia toosendan%n-butanol fraction%acute toxicity%LD50
为探明川楝子正丁醇部位的急性毒性,通过预试验测定出川楝子正丁醇部位的最小全死量(Dm)和最大全不死量(Dn),然后进行川楝子正丁醇部位对小白鼠的急性毒性试验。结果表明:川楝子乙醇提取物的正丁醇部位对小白鼠单次口服的半数致死量(LD50)为2.7571 g/kg,95%可信限为2.7419~2.7723 g/kg。死亡小白鼠急性毒性主要表现为安静少动、腹卧昏睡、呼吸急促、连续抽搐。川楝子正丁醇部位毒性较低,符合低毒化合物标准(500~5000 mg/kg)。
為探明川楝子正丁醇部位的急性毒性,通過預試驗測定齣川楝子正丁醇部位的最小全死量(Dm)和最大全不死量(Dn),然後進行川楝子正丁醇部位對小白鼠的急性毒性試驗。結果錶明:川楝子乙醇提取物的正丁醇部位對小白鼠單次口服的半數緻死量(LD50)為2.7571 g/kg,95%可信限為2.7419~2.7723 g/kg。死亡小白鼠急性毒性主要錶現為安靜少動、腹臥昏睡、呼吸急促、連續抽搐。川楝子正丁醇部位毒性較低,符閤低毒化閤物標準(500~5000 mg/kg)。
위탐명천련자정정순부위적급성독성,통과예시험측정출천련자정정순부위적최소전사량(Dm)화최대전불사량(Dn),연후진행천련자정정순부위대소백서적급성독성시험。결과표명:천련자을순제취물적정정순부위대소백서단차구복적반수치사량(LD50)위2.7571 g/kg,95%가신한위2.7419~2.7723 g/kg。사망소백서급성독성주요표현위안정소동、복와혼수、호흡급촉、련속추휵。천련자정정순부위독성교저,부합저독화합물표준(500~5000 mg/kg)。
To evaluate the acute toxicity of the n-butanol fraction from M.toosendan,minimum amount of Dm and the maximum amount of Dn of the n-butanol fraction from M.toosendan was measured by preliminary test.Then design a test to evaluate the acute toxicity for mice.The results showed that the LD50 of n-butanol fraction from M.toosendan on single dose in mice was 2.757 1 g/kg,95% confidence-limit was 2.741 9 ~ 2.772 3 g/kg.The main acute toxicity symptoms and signs of dead mice included negligent action,shortness of breath,continuous convulsions.According to the national standard of acute toxicity test,the n-butanol fraction from M.toosendan belonged to low-toxic compounds.