动物医学进展
動物醫學進展
동물의학진전
PROGRESS IN VETERINARY MEDICINE
2015年
1期
121-127
,共7页
底丽娜%赵红琼%夏利宁%南海辰
底麗娜%趙紅瓊%夏利寧%南海辰
저려나%조홍경%하리저%남해신
动物源%大肠埃希菌%抗菌药物%耐药%最小抑菌浓度
動物源%大腸埃希菌%抗菌藥物%耐藥%最小抑菌濃度
동물원%대장애희균%항균약물%내약%최소억균농도
animal source%E .coli%antimicrobial drug%drug resistance%minimum inhibitory concentration
为了比较新疆不同动物源大肠埃希菌对临床常用抗菌药物的耐药情况。从猪场、羊场和牛场分别分离猪源大肠埃希菌454株、羊源大肠埃希菌638株和牛源大肠埃希菌89株。用微量肉汤法对上述菌进行临床常用β‐内酰胺类、氟喹诺酮类、氨基糖苷类和酰胺醇类抗菌药物最小抑菌浓度测定。猪源大肠埃希菌对氨苄西林（67．0％）和阿莫西林／克拉维酸（63．7％）耐药率较高，其他药物耐药率在10．4％～41．2％之间；羊源大肠埃希菌对安普霉素（33．9％）和阿莫西林／克拉维酸（21．2％）耐药率较高，其他药物耐药率在3．1％～15．6％之间；牛源大肠埃希菌对氨苄西林（24．4％）和阿莫西林／克拉维酸（8．9％）耐药率较高，其他药物耐药率在1．1％～6．7％之间。多药耐药结果：猪源大肠埃希菌以2耐～5耐为主，羊源大肠埃希菌以0耐～2耐为主，牛源大肠埃希菌以0耐～1耐为主。新疆猪源大肠埃希菌对临床常用抗菌药物耐药情况最严重，羊源菌次之，牛源菌最轻；猪源大肠埃希菌多药耐药现象严重。
為瞭比較新疆不同動物源大腸埃希菌對臨床常用抗菌藥物的耐藥情況。從豬場、羊場和牛場分彆分離豬源大腸埃希菌454株、羊源大腸埃希菌638株和牛源大腸埃希菌89株。用微量肉湯法對上述菌進行臨床常用β‐內酰胺類、氟喹諾酮類、氨基糖苷類和酰胺醇類抗菌藥物最小抑菌濃度測定。豬源大腸埃希菌對氨芐西林（67．0％）和阿莫西林／剋拉維痠（63．7％）耐藥率較高，其他藥物耐藥率在10．4％～41．2％之間；羊源大腸埃希菌對安普黴素（33．9％）和阿莫西林／剋拉維痠（21．2％）耐藥率較高，其他藥物耐藥率在3．1％～15．6％之間；牛源大腸埃希菌對氨芐西林（24．4％）和阿莫西林／剋拉維痠（8．9％）耐藥率較高，其他藥物耐藥率在1．1％～6．7％之間。多藥耐藥結果：豬源大腸埃希菌以2耐～5耐為主，羊源大腸埃希菌以0耐～2耐為主，牛源大腸埃希菌以0耐～1耐為主。新疆豬源大腸埃希菌對臨床常用抗菌藥物耐藥情況最嚴重，羊源菌次之，牛源菌最輕；豬源大腸埃希菌多藥耐藥現象嚴重。
위료비교신강불동동물원대장애희균대림상상용항균약물적내약정황。종저장、양장화우장분별분리저원대장애희균454주、양원대장애희균638주화우원대장애희균89주。용미량육탕법대상술균진행림상상용β‐내선알류、불규낙동류、안기당감류화선알순류항균약물최소억균농도측정。저원대장애희균대안변서림（67．0％）화아막서림／극랍유산（63．7％）내약솔교고，기타약물내약솔재10．4％～41．2％지간；양원대장애희균대안보매소（33．9％）화아막서림／극랍유산（21．2％）내약솔교고，기타약물내약솔재3．1％～15．6％지간；우원대장애희균대안변서림（24．4％）화아막서림／극랍유산（8．9％）내약솔교고，기타약물내약솔재1．1％～6．7％지간。다약내약결과：저원대장애희균이2내～5내위주，양원대장애희균이0내～2내위주，우원대장애희균이0내～1내위주。신강저원대장애희균대림상상용항균약물내약정황최엄중，양원균차지，우원균최경；저원대장애희균다약내약현상엄중。
In order to compare the antimicrobial drug resistance of E .coli isolates to from different animals in Xinjiang ,454 isolates from pigs ,638 isolates from sheep and 89 isolates from cattle were conformed . Minimal inhibitory concentrations (MIC) of the antimicrobial drugs (including β‐lactams ,fluoroquinolo‐nes ,aminoglycosides and phenicol) to these isolates from pigs ,sheep and cattle were determined by the broth micro‐dilution method .The resistance rates of E .coli from pigs to ampicillin and amoxicillin/clavu‐lanic acid were 67 .0% and 63 .7% ,respectively ,resistance rates to other drugs between 10 .4%‐41 .2% ;the resistance rates of E .coli from sheep to apramycin and amoxicillin/clavulanic acid were 33 .9% and 21 . 2% ,respectively ,resistance rates to other drugs between 3 .1%‐15 .6% ;the resistance rates of E .coli from cattle to ampicillin and amoxicillin/clavulanic acid were 24 .4% and 8 .9% ,respectively ,resistance rates to other drugs between 1 .1%‐6 .7% .Multidrug resistance results ,showed that resistance to 2‐5 an‐timicrobials was dominated among E .coli isolates from pigs ;resistance to 0‐2 antimicrobials was domina‐ted among E .coli isolates from sheep ;resistance to 0‐1 antimicrobial was dominated among E .coli iso‐lates from cattle .Serious degree of resistance of E .coli to antimicrobial drugs descending order was iso‐lates from pig ,sheep and cattle ;multidrug resistance of E .coli from pigs was the most serious in Xin‐jiang .
