CAJ | 학술논문

自2001年欧盟实施疯牛病主动监测以后，人们发现一种新的与典型疯牛病不一样的疯牛病，即非典型疯牛病。后来，在日本、加拿大、美国、巴西等也发现非典型疯牛病。目前普遍认为，该类疯牛病多发于老年牛，临床上有的表现症状，有的无症状，具有自发性和散发性特征，发病率低，约为百万份之一至百万份之三。研究发现，非典型疯牛病可以分为 H型和L型，两者在PK酶抗性、糖基化、传染性、机体内分布等存在差异，同时与典型疯牛病也存在明显差异。比较来看，L型疯牛病的传染性最强，H型疯牛病的较弱。论文从非典型疯牛病的临床症状、病理变化、病原分布及分子特性、传染性等方面做了详细介绍。
자2001년구맹실시풍우병주동감측이후，인문발현일충신적여전형풍우병불일양적풍우병，즉비전형풍우병。후래，재일본、가나대、미국、파서등야발현비전형풍우병。목전보편인위，해류풍우병다발우노년우，림상상유적표현증상，유적무증상，구유자발성화산발성특정，발병솔저，약위백만빈지일지백만빈지삼。연구발현，비전형풍우병가이분위 H형화L형，량자재PK매항성、당기화、전염성、궤체내분포등존재차이，동시여전형풍우병야존재명현차이。비교래간，L형풍우병적전염성최강，H형풍우병적교약。논문종비전형풍우병적림상증상、병리변화、병원분포급분자특성、전염성등방면주료상세개소。
Since the active surveillance of bovine spongiform encephalopathy (BSE) was implemented in EU in 2001 ,a new kind of BSE ,namely atypical BSE ,which was different from classical BSE was emerged . Subsequently ,atypical BSEs were also found in Japan ,Canada ,America ,Brazil ,and so on .It is widely accepted that this kind of BSE was often observed within old cattle with or without clinical signs .The ap‐parent incidence of atypical BSE was low ,approximately 1‐3 cases per million cattle .It was characterized by spontaneity and sporadicness .Experimental evidence showed that atypical BSE included H‐type and L‐type cases which were distinct from protease K resistant ,glycosylation ,transmission ,agent distribution in vivo ,and so on .Meanwhile ,there was obvious difference between atypical and classical BSE .L‐BSE had stronger transmissibility by comparison with H‐BSE .This paper introduced clinic symptoms ,patho‐logical lesions ,agent distribution ,molecular feature ,transmissibility of atypical BSE in detail .