中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
1期
11-13
,共3页
牛肺磷脂注射液%新生儿%胎粪吸入综合征%鼻塞持续气道正压
牛肺燐脂註射液%新生兒%胎糞吸入綜閤徵%鼻塞持續氣道正壓
우폐린지주사액%신생인%태분흡입종합정%비새지속기도정압
bovine lung phospholipid injection%newbom%severe meconium aspiration syndrome%nasal continuous positive airway pressure
目的：探讨牛肺磷脂注射液联合鼻塞持续气道正压（ NCPAP ）治疗重症新生儿胎粪吸入综合征（ MAS）的临床疗效。方法2013年在我科收治的重症MAS病例中选取36例，根据是否使用牛肺磷脂注射液分为2组，对照组给予NCPAP治疗，治疗组采用牛肺磷脂注射液联合NCPAP治疗，动态观察使用牛肺磷脂注射液后4，12，24，48 h患儿的氧分压（ PaO2）和二氧化碳分压（PaCO2）、吸入氧浓度（FiO2）及呼吸末正压（PEEP）的情况，并统计NCPAP通气时间、氧疗时间、改行有创机械通气病例数。结果在治疗后各时间点，治疗组的血 PaO2、血 pH 值高于对照组，血 PaCO2﹑吸氧浓度和PEEP低于对照组，同时，治疗组的 CPAP使用时间﹑氧疗时间﹑改行有创机械通气病例数低于对照组，差异有统计学意义（ P＜0．05）。结论牛肺磷脂注射液联合NCPAP治疗重症MAS效果显著。
目的：探討牛肺燐脂註射液聯閤鼻塞持續氣道正壓（ NCPAP ）治療重癥新生兒胎糞吸入綜閤徵（ MAS）的臨床療效。方法2013年在我科收治的重癥MAS病例中選取36例，根據是否使用牛肺燐脂註射液分為2組，對照組給予NCPAP治療，治療組採用牛肺燐脂註射液聯閤NCPAP治療，動態觀察使用牛肺燐脂註射液後4，12，24，48 h患兒的氧分壓（ PaO2）和二氧化碳分壓（PaCO2）、吸入氧濃度（FiO2）及呼吸末正壓（PEEP）的情況，併統計NCPAP通氣時間、氧療時間、改行有創機械通氣病例數。結果在治療後各時間點，治療組的血 PaO2、血 pH 值高于對照組，血 PaCO2﹑吸氧濃度和PEEP低于對照組，同時，治療組的 CPAP使用時間﹑氧療時間﹑改行有創機械通氣病例數低于對照組，差異有統計學意義（ P＜0．05）。結論牛肺燐脂註射液聯閤NCPAP治療重癥MAS效果顯著。
목적：탐토우폐린지주사액연합비새지속기도정압（ NCPAP ）치료중증신생인태분흡입종합정（ MAS）적림상료효。방법2013년재아과수치적중증MAS병례중선취36례，근거시부사용우폐린지주사액분위2조，대조조급여NCPAP치료，치료조채용우폐린지주사액연합NCPAP치료，동태관찰사용우폐린지주사액후4，12，24，48 h환인적양분압（ PaO2）화이양화탄분압（PaCO2）、흡입양농도（FiO2）급호흡말정압（PEEP）적정황，병통계NCPAP통기시간、양료시간、개행유창궤계통기병례수。결과재치료후각시간점，치료조적혈 PaO2、혈 pH 치고우대조조，혈 PaCO2﹑흡양농도화PEEP저우대조조，동시，치료조적 CPAP사용시간﹑양료시간﹑개행유창궤계통기병례수저우대조조，차이유통계학의의（ P＜0．05）。결론우폐린지주사액연합NCPAP치료중증MAS효과현저。
Objective To investigate the clinical efects of bovine lung phospholipid injection ( Kelisu ) combined nasal continuous positive airway pressure ( NCPAP ) for treating severe meconium aspiration syndrome( MAS).Methods Thirty-six infants with MAS in our de-partment were selected, and divided into two groups according to whether or not to use Kelisu.Control group were given NCPAP thera-py, treatment group were treated with Kelisu combined NCPAP.After using Kelisu 4, 12, 24, 48 h, blood PaCO2, blood PaO2, blood pH, FiO2 and PEEP were observed.We also observed the time of u-sing NCPAP, the oxygen cure time, the number of cases of diverted mechanical ventilation.Results Compared with the control group, the blood PaO2, blood pH after 4,12,24,48h treatment of the treat-ment group were higher,the blood PaCO2 , FiO2 and PEEP were low-er, and the time of using NCPAP, the oxygen cure time, the number of cases of diverted mechanical ventilation were less ( P <0.05 ) . Conclusion Bovine lung phospholipid injection fcombined NCPAP for treating severe meconium aspiration syndrome has better efects and is worth clinical application.
