CAJ | 학술논문

目的：探讨非酒精性脂肪性肝病（ NAFLD）患者血清β抑制蛋白（ ARRB）表达情况及临床意义。方法将83例NAFLD患者分为非酒精性脂肪肝的无纤维化组与纤维化组（分别简称为无纤维化组与纤维化组），分别进行血清ARRB 1、ARRB 2、胰岛素及空腹血糖检测，并与20例健康者进行比较。结果纤维化组患者的血清ARRB1、ARRB2及胰岛素水平显著高于无纤维化组及健康组（ P＜0．05），但3组血清空腹血糖水平差别无统计学意义（ P＞0．05）。结论ARRB可能参与了NAFLD的肝纤维化进展。
목적：탐토비주정성지방성간병（ NAFLD）환자혈청β억제단백（ ARRB）표체정황급림상의의。방법장83례NAFLD환자분위비주정성지방간적무섬유화조여섬유화조（분별간칭위무섬유화조여섬유화조），분별진행혈청ARRB 1、ARRB 2、이도소급공복혈당검측，병여20례건강자진행비교。결과섬유화조환자적혈청ARRB1、ARRB2급이도소수평현저고우무섬유화조급건강조（ P＜0．05），단3조혈청공복혈당수평차별무통계학의의（ P＞0．05）。결론ARRB가능삼여료NAFLD적간섬유화진전。
Objective To evaluate the clinical significance of the deter-mination on the β-arrestin serum ( AEEB ) expression in patients with non nalcoholic fatty liver disease( NAFLD).Methods Total of the 83 ca-ses with NAFLD divided into two groups: nonalcoholic fatty liver with fi-brosis group ( A group) and nonalcoholic fatty liver without fibrosis group ( B group ) . Twenty health subjects was as healthy control group ( C group) .All of the included subjects were tested for serumβ-arrestin 1,β-arrestin 2, insulin(INS) and fasting plasma glucose.Results The serumβ-arrestin 1,β-arrestin 2, INS in group A were much higher than that in group B and group C with statistical difference(P<0.05).But the fasting plasma glucose level in serum was not statistical difference ( P >0.05).Conclusion β-arrestin may participate in the development of nalcoholic fatty liver disease.