CAJ | 학술논문

目的：探讨温阳方联合西药治疗慢性心力衰竭（ CHF）的临床疗效。方法70例CHF 患者随机分温阳方＋西药治疗组35例（试验组）和西药治疗组35例（对照组）。对照组给予降血压、β受体阻滞剂、利尿剂、强心等药物治疗；试验组在对照组的基础上予以温阳方，2组患者治疗1个月。治疗1个月后评价2组患者神经内分泌指标及左室射血分数（LVEF）。结果治疗1个月后，试验组与对照组血浆去甲肾上腺素（NE）、血管紧张素Ⅱ（AngⅡ）和醛固醇（ALD）均明显降低（P ＜0．05），左室射血分数（LVEF）均显著升高（P ＜0．05），但试验组与对照组相比变化更为显著（P ＜0．05）。治疗后试验组总有效率显著高于对照组（P ＜0．05）。结论温阳方联合西药治疗CHF 可显著提高LVEF，改善心力衰竭症状。
목적：탐토온양방연합서약치료만성심력쇠갈（ CHF）적림상료효。방법70례CHF 환자수궤분온양방＋서약치료조35례（시험조）화서약치료조35례（대조조）。대조조급여강혈압、β수체조체제、이뇨제、강심등약물치료；시험조재대조조적기출상여이온양방，2조환자치료1개월。치료1개월후평개2조환자신경내분비지표급좌실사혈분수（LVEF）。결과치료1개월후，시험조여대조조혈장거갑신상선소（NE）、혈관긴장소Ⅱ（AngⅡ）화철고순（ALD）균명현강저（P ＜0．05），좌실사혈분수（LVEF）균현저승고（P ＜0．05），단시험조여대조조상비변화경위현저（P ＜0．05）。치료후시험조총유효솔현저고우대조조（P ＜0．05）。결론온양방연합서약치료CHF 가현저제고LVEF，개선심력쇠갈증상。
Objective To evaluate the clinical effects of Wenyang in the treatment of chronic heart failure ( CHF ) .Methods Seventy patients with CHF were recruited and randomly divided into experiment group ( n=35 ) and control group ( n=35 ) .Patients in the experiment group were treated with Wenyangfang and west medicine;patients in the control group were treated with west medicine only.All the patients were treated 1 month.After 1 month treatment, the neuroendocrine indicators and LVEF were compared between the two groups.Results After treatment of 1 month, the norepinephrine, angiotensin Ⅱ( AngⅡ) , aldosterone ( ALD ) were decreased in both experiment and control group ( P <0.05), the left ventricular ejection fraction(LVEF) was both improved in the two groups.And the experiment group was much significant than that of control group ( P <0.05 ) .The total efficacy in the experiment group was much higher than that of control group ( P <0.05 ) . Conclusion Wenyangfang combined with the medicine can significant improve the LVEF and symptom in patients with CHF.