CAJ | 학술논문

目的：测量北京顺义区正常成年人群腰椎骨密度( bone mineral density,BMD),了解人群BMD规律及骨质疏松流行病学情况,为我国北方地区正常人群BMD数据库的确立提供数据；探讨容积性定量CT ( volumet-ric QCT,vQCT)在椎体BMD测定及诊断骨质疏松中的价值。方法采用vQCT测量835例正常人腰椎1~3 BMD,按性别和年龄分组进行统计学分析,计算各组骨量正常、骨量减少及骨质疏松发生率。结果腰椎BMD峰值在18~30岁年龄组,男性为(165.22±26.97)mg/cm3,女性为(175.01±28.47)mg/cm3；男女两组各年龄段间3个腰椎BMD值间差异均有显著性(P均<0.001)；腰椎1~3 BMD值呈现递减趋势,各椎体间BMD差异只有女性40~49岁组及50~59岁组有显著性( F值、P值分别为5.377,0.005；7.429,0.001)。男、女组BMD与年龄均呈负相关,r分别为-0.685(P<0.001)、-0.604(P<0.001)。男性随年龄增长骨质疏松患病率逐渐增高,到≥70岁组达64.81%(35/54)；女性40~49岁组原发性骨质疏松患病率仅3.33%(3/90),50岁以后,骨质疏松患病率迅速增高,到≥70岁组骨质疏松患病率达82.14%(23/28)。结论掌握了本地区正常成年人群BMD特点及骨质疏松流行病学情况,vQCT椎体BMD测定诊断骨质疏松敏感性高,女性近50岁、男性近60岁就应该预防性检查BMD,腰椎vQCT 测量BMD对老年人群更合适。
목적：측량북경순의구정상성년인군요추골밀도( bone mineral density,BMD),료해인군BMD규률급골질소송류행병학정황,위아국북방지구정상인군BMD수거고적학립제공수거；탐토용적성정량CT ( volumet-ric QCT,vQCT)재추체BMD측정급진단골질소송중적개치。방법채용vQCT측량835례정상인요추1~3 BMD,안성별화년령분조진행통계학분석,계산각조골량정상、골량감소급골질소송발생솔。결과요추BMD봉치재18~30세년령조,남성위(165.22±26.97)mg/cm3,녀성위(175.01±28.47)mg/cm3；남녀량조각년령단간3개요추BMD치간차이균유현저성(P균<0.001)；요추1~3 BMD치정현체감추세,각추체간BMD차이지유녀성40~49세조급50~59세조유현저성( F치、P치분별위5.377,0.005；7.429,0.001)。남、녀조BMD여년령균정부상관,r분별위-0.685(P<0.001)、-0.604(P<0.001)。남성수년령증장골질소송환병솔축점증고,도≥70세조체64.81%(35/54)；녀성40~49세조원발성골질소송환병솔부3.33%(3/90),50세이후,골질소송환병솔신속증고,도≥70세조골질소송환병솔체82.14%(23/28)。결론장악료본지구정상성년인군BMD특점급골질소송류행병학정황,vQCT추체BMD측정진단골질소송민감성고,녀성근50세、남성근60세취응해예방성검사BMD,요추vQCT 측량BMD대노년인군경합괄。
Objective To observe the change regularity of lumbar BMD values of different age in Shunyi area,so as to provide basis for clinical prevention and treatment of osteoporosis;and to provide data for the northern area of China BMD database;discuss the value of vQCT in measuring BMD and osteoporosis diagnosis. Method Lumbar( L1 ~L3 ) BMD of 835 healthy individuals were measured with QCT,all the people were divided into 12 groups according to their age and sex. The data was analyzed. Result The result indicated that for both male and female the peak BMD (PMD) comes at 18~30 years old. The numerical value is (165. 22±26. 97)mg/cm3 and (175. 01±28. 47)mg/cm3. The BMD and age were negatively correlated in male and female group,the correlation coefficients were:-0. 685 (P<0.001),-0.604(P<0. 001) respectively. The incidence of osteoporosis was 5. 19%(4/77) in male,and 3. 33%(3/90) in female in the age group of 40~49,after the age of 50,with the growth of the age the incidence of OP increased rapidly,to 70 years of age or older the incidence was 82. 14%(23/28) in female,and 64. 81%(35/54) in male. Conclusion This study accumulates data for obtaining normal lumbar BMD value in Shunyi area. As a method for diagnosing osteoporosis, vQCT is highly sensitive, precise, reproducible and is easily applied. Lumbar vQCT measurement of BMD is more suitable for the elderly.