CAJ | 학술논문

目的了解O- GIcNAc转移酶(O- GlcNAc transferase，OGT)在直肠癌中的表达情况及对预后的影响。方法利用免疫组化技术，在直肠癌组织芯片上染色OGT，确定表达情况，并与患者临床资料结合，了解OGT的表达与直肠癌患者的生存是否有差异。结果 OGT在直肠癌组织中的表达情况：“-”12.22%、“+”27.78%、“++”44.44%、“+++”15.56%,癌旁组织中的表达情况：“-”18.89%、“+”42.22%、“++”37.78%、“+++”1.11%；癌组织中OGT高表达（++和+++）为60.00%，高于癌旁组织中OGT高标的量38.89%；OGT高表达直肠癌患者的3年生存率分别是82.90%和60.00%，两者比较有统计学差异（字2=7.452，P=0.006）。结论OGT在直肠癌中的表达高于周围正常组织，直肠癌中高表达的3年生存率较低，OGT可能参加了肿瘤的发生、发展过程。
목적료해O- GIcNAc전이매(O- GlcNAc transferase，OGT)재직장암중적표체정황급대예후적영향。방법이용면역조화기술，재직장암조직심편상염색OGT，학정표체정황，병여환자림상자료결합，료해OGT적표체여직장암환자적생존시부유차이。결과 OGT재직장암조직중적표체정황：“-”12.22%、“+”27.78%、“++”44.44%、“+++”15.56%,암방조직중적표체정황：“-”18.89%、“+”42.22%、“++”37.78%、“+++”1.11%；암조직중OGT고표체（++화+++）위60.00%，고우암방조직중OGT고표적량38.89%；OGT고표체직장암환자적3년생존솔분별시82.90%화60.00%，량자비교유통계학차이（자2=7.452，P=0.006）。결론OGT재직장암중적표체고우주위정상조직，직장암중고표체적3년생존솔교저，OGT가능삼가료종류적발생、발전과정。
Objective To investigate the expression of O- GIcNAc transferase (OGT) and its relation to prognosis in rectal cancer. Methods The expression of OGT was detected with immunohistochemical technique on rectal cancer tissue microarray. The association of OGT expression with survival of patients was analyzed. Results The high OGT expression (++and+++) rate in rectal cancer was higher than that in pericancerous tissue (60.0%vs 38.9%, P<0.05). The 3- years survival rate in patients with high OGT expression was lower than that with low expression (60.0%vs 82.9%,χ2=7.452, P=0.006). Conclusion OGT ex-pression in rectal cancer is higher than that in normal tissue. Rectal cancer patients with high OGT expression may have less fa-vorable prognosis than those with low OGT expression.