CAJ | 학술논문

目的：探讨＞70岁老年患者慢性胃炎中胃蛋白酶原（PG）Ⅰ、Ⅱ变化及临床意义。方法选择经胃镜和病理诊断的慢性胃炎240例，分为＞70岁老年研究组（慢性非萎缩性胃炎60例+慢性萎缩性胃炎60例）和20~60岁的中青年对照组（慢性非萎缩性胃炎60例+慢性萎缩性胃炎60例）。分别测定患者血清中的PGⅠ、PGⅡ，计算PGⅠ/PGⅡ（PGR）。结果对照组中慢性非萎缩性胃炎和慢性萎缩性胃炎患者PGⅠ、PGR有统计学差异（P＞0.05）；研究组中慢性萎缩性胃炎较慢性非萎缩性胃炎患者PGⅠ、PGR明显下降（P＜0.05）；研究组较对照组PGⅠ、PGR降低（P＜0.05）。根据ROC曲线＞70岁老年慢性萎缩性胃炎患者PGⅠ和PGR的界值分别为97.25μg/L、6.75。结论血清PG检测对老年患者慢性萎缩性胃炎的筛查有意义，针对老年患者需进一步研究确定其参考范围。
목적：탐토＞70세노년환자만성위염중위단백매원（PG）Ⅰ、Ⅱ변화급림상의의。방법선택경위경화병리진단적만성위염240례，분위＞70세노년연구조（만성비위축성위염60례+만성위축성위염60례）화20~60세적중청년대조조（만성비위축성위염60례+만성위축성위염60례）。분별측정환자혈청중적PGⅠ、PGⅡ，계산PGⅠ/PGⅡ（PGR）。결과대조조중만성비위축성위염화만성위축성위염환자PGⅠ、PGR유통계학차이（P＞0.05）；연구조중만성위축성위염교만성비위축성위염환자PGⅠ、PGR명현하강（P＜0.05）；연구조교대조조PGⅠ、PGR강저（P＜0.05）。근거ROC곡선＞70세노년만성위축성위염환자PGⅠ화PGR적계치분별위97.25μg/L、6.75。결론혈청PG검측대노년환자만성위축성위염적사사유의의，침대노년환자수진일보연구학정기삼고범위。
Objective To investigate the serum levels of pepsinogen (PG)ⅠandⅡ in elderly patients with chronic gas-tritis and its clinical significance. Methods One hundred and twenty patients with chronic gastritis aged over 70y, including 60 cases of atrophic gastritis and 60 of non- atrophic gastritis were enrol ed in the study as elderly group, 120 patients aged 20~60y, including 60 cases of atrophic gastritis and 60 of non- atrophic gastritis served as control group. Serum PGⅠand PGⅡ levels were measured and the ratio of PGⅠ/PGⅡ (PGR) was calculated. Results There were different significance of PGⅠand PGR between non- atrophic chronic gastritis patients and atrophic chronic gastritis patients in control group. While in case group, the PGⅠand PGR levels in non- atrophic chronic gastritis patients were lower than that of atrophic chronic gastritis patients(P<0.05). The PGⅠand PGR levels in case group were lower than that of control group (P<0.05). According to ROC cure, the cut- off of PGⅠand PGR was 97.25μg/L and 6.75 respectively in chronic gastritis patients over 70 years old. Conclusion Serum PG mea-surement could be used to screen elder chronic atrophic gastritis patients. And its medical reference change should be further explored.