CAJ | 학술논문

目的：评估低碳水化合物饮食对非酒精性脂肪肝肥胖患者体重和代谢综合征的影响。方法在3个月内对16例成年非酒精性脂肪肝肥胖患者，予以低碳水化合物饮食指导进行减重干预（碳水化合物占总供能比20％～40％，蛋白质占30％～60％，脂肪占20％～30％）。在干预前后分别检测16例参与者体重、体成分、血压等，空腹抽血测定丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿素、肌酐、尿酸和血糖等。结果16例患者采用3个月内的低碳水化合物减重干预后体重、身体质量指数、体脂肪、体脂肪百分比、内脏脂肪面积、腰围、腰臀比等，与干预前比较差异均有统计学意义（P＜0．05）。但是，骨骼肌含量也呈现一定程度地下降。患者减重干预后舒张压、空腹葡萄糖、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、胆固醇、三酰甘油、低密度脂蛋白胆固醇及尿酸水平均有所改善（P＜0．05）；而收缩压、高密度脂蛋白胆固醇，尤其是尿素和肌酐的改善并不显著（P＞0．05），说明减重过程中采用的特殊饮食模式未对肾功能产生不良影响。结论低碳水化合物饮食可以在短期内减轻非酒精性脂肪肝肥胖患者的体重并改善代谢综合征相关指标。
목적：평고저탄수화합물음식대비주정성지방간비반환자체중화대사종합정적영향。방법재3개월내대16례성년비주정성지방간비반환자，여이저탄수화합물음식지도진행감중간예（탄수화합물점총공능비20％～40％，단백질점30％～60％，지방점20％～30％）。재간예전후분별검측16례삼여자체중、체성분、혈압등，공복추혈측정병안산안기전이매、천문동안산안기전이매、삼선감유、총담고순、고밀도지단백담고순、저밀도지단백담고순、뇨소、기항、뇨산화혈당등。결과16례환자채용3개월내적저탄수화합물감중간예후체중、신체질량지수、체지방、체지방백분비、내장지방면적、요위、요둔비등，여간예전비교차이균유통계학의의（P＜0．05）。단시，골격기함량야정현일정정도지하강。환자감중간예후서장압、공복포도당、병안산안기전이매、천문동안산안기전이매、담고순、삼선감유、저밀도지단백담고순급뇨산수평균유소개선（P＜0．05）；이수축압、고밀도지단백담고순，우기시뇨소화기항적개선병불현저（P＞0．05），설명감중과정중채용적특수음식모식미대신공능산생불량영향。결론저탄수화합물음식가이재단기내감경비주정성지방간비반환자적체중병개선대사종합정상관지표。
Objective To evaluating the effects of low-carbohydrate diet on body weight as well as on metabolic markers . Methods In a three-month uncontrolled study , 16 obese subjects with NAFLD were placed on a low-carbohydrate diet (20%-40%from carbohydrate, 30%-60%from protein, 20%-30%from fat;low glycemic load).At baseline and 3 months, measures included anthropometrics, body composition, blood pressure.Markers of liver function alanine aminotransferase (ALT), aspartate aminotrans-ferase (AST), total lipid profile, urea nitrogen, creatinine, uric acid and glucose were measured in fasting blood .Results In 3 months, a significant reduction in weight , body mass index, body fat, percentage of body fat, visceral fat area, waist circumference and waist-hip ratio were observed (both P<0.05 compared with baseline values ).In obese subjects with NAFLD the diastolic pres-sure, ALT, AST, triglycerides, total cholesterol, LDL cholesterol, uric acid and glucose levels were decreased to a greater extent after 3-month low-carbohydrate diet(P<0.05), without statistical changes in systolic pressure and HDL cholesterol (P>0.05).Conclu-sion A low-carbohydrate diet result in weight loss and may improve markers of the metabolic syndrome in the short time .