CAJ | 학술논문

目的：研究新疆乳腺癌患者血清微量元素锰（Mn）、铜（Cu）、锌（Zn）、硒（Se）的含量变化及其对乳腺癌的意义。方法选择2011年5月－2012年7月入住新疆医科大学附属肿瘤医院的新疆常住各族女性已确诊的原发性乳腺癌患者155例（病例组）及体检健康者155例（对照组），按照1∶1配比的病例对照研究，采用原子吸收分光光度法测定乳腺癌患者和对照组血清中微量元素 Mn、Cu、Zn、Se的含量。结果经单因素分析，病例组和对照组Mn、Zn含量和Cu／Zn含量差异有统计学意义（P ＜0．05）。在不同临床病理分级中血清 Cu、Cu／Zn差异有统计学意义（P ＜0．05），在不同年龄分组中血清Se差异有统计学意义（P ＜0．05）。PR阴性组PR阳性组血清Mn、Cu、Zn及Cu／Zn差异有统计学意义。Cu／Zn在 ER阴性组和阳性组中差异有统计学意义。结论对微量元素的检测可能有助于乳腺癌的早期预防和预后。
목적：연구신강유선암환자혈청미량원소맹（Mn）、동（Cu）、자（Zn）、서（Se）적함량변화급기대유선암적의의。방법선택2011년5월－2012년7월입주신강의과대학부속종류의원적신강상주각족녀성이학진적원발성유선암환자155례（병례조）급체검건강자155례（대조조），안조1∶1배비적병례대조연구，채용원자흡수분광광도법측정유선암환자화대조조혈청중미량원소 Mn、Cu、Zn、Se적함량。결과경단인소분석，병례조화대조조Mn、Zn함량화Cu／Zn함량차이유통계학의의（P ＜0．05）。재불동림상병리분급중혈청 Cu、Cu／Zn차이유통계학의의（P ＜0．05），재불동년령분조중혈청Se차이유통계학의의（P ＜0．05）。PR음성조PR양성조혈청Mn、Cu、Zn급Cu／Zn차이유통계학의의。Cu／Zn재 ER음성조화양성조중차이유통계학의의。결론대미량원소적검측가능유조우유선암적조기예방화예후。
Objective The aim of this study was to investigate the trace elements (Mn,Cu,Se,Zn) content changes and the implication of these changes for breast cancer.Methods We collected 1 5 5 cases of primary breast cancer and 155 cases of healthy people from.The Affiliated Tumor Hospital of Xinjiang Medical University Between May 2011 and July 2012.1∶1 case-control method was adopted and the con-tent of trace elements in serum was determined by atomic absorption spectrophotometry.Results Univari-ate analysis showed that the difference of the content of Mn,Zn and Cu/Zn in people from two groups had statistic significance (P <0.05).The difference of the content of Cu and Cu/Zn in serum was statistically significant according to the histological grading (P <0.05);The difference of the content of Se in serum was statistically significant in terms of age (P <0.05).Conclusion Detection of trace elements may con-tribute to early detection and help prognosis in breast cancer.