CAJ | 학술논문

肾脏发育是一个复杂的过程，需要在输尿管芽细胞和基质细胞相互诱导下，引起细胞生长、增殖、分化，从而产生肾单位及各种管状结构，最终发育为成熟的肾脏。在肾脏发育过程中，GDNF/Ret、Wnt、BMP 等一系列信号通路参与了发育的调控过程。这些信号通路在肾脏发育的不同阶段或不同位置发挥着重要的调控作用，并且通路之间存在相互的调控，从而形成了一个复杂而精细的调控网络，保证了肾脏的正常发育。文章概括了肾脏发育的过程，总结了肾脏发育过程中相关信号通路对肾脏发育的调控作用以及信号通路之间的相互调控。
신장발육시일개복잡적과정，수요재수뇨관아세포화기질세포상호유도하，인기세포생장、증식、분화，종이산생신단위급각충관상결구，최종발육위성숙적신장。재신장발육과정중，GDNF/Ret、Wnt、BMP 등일계렬신호통로삼여료발육적조공과정。저사신호통로재신장발육적불동계단혹불동위치발휘착중요적조공작용，병차통로지간존재상호적조공，종이형성료일개복잡이정세적조공망락，보증료신장적정상발육。문장개괄료신장발육적과정，총결료신장발육과정중상관신호통로대신장발육적조공작용이급신호통로지간적상호조공。
The development of mammalian kidney is a complex process. The reciprocal inductive interac-tions between epithelial cells and metanephric mesenchymal cells determine cell fates including proliferation, growth, apoptosis, and eventually contribute to the formation of an intact kidney. Multiple signaling pathways, including the GDNF/Ret, Wnt and BMP signaling pathways, have been shown to regulate the development of kidney. A myriad of signaling pathways and their cross-talks form a precise spatiotemporal regulatory network, which ensures the kidney to be properly organized. In this review, we summarize the physiological process of kidney development as well as the involved signaling pathways and their interplay.