CAJ | 학술논문

目的：提高完善胃炎灵片剂的质量标准。方法：参照国家最新药品标准在原有质量标准的基础上，新增采用薄层色谱（TLC）对处方中的党参、黄芪、木香、白芍进行定性鉴别，同时新增紫外分光光度法对黄连中盐酸小檗碱进行含量测定。结果：薄层色谱斑点清晰集中，专属性强；紫外分光光度法测得盐酸小檗碱的含量在0～5.0μg/mL范围内与吸光度有良好的线性关系，其线性方程A =0.0638C ＋0.0014，r =0.9998，平均回收率为99.78%， RSD为0.27%（n =6）。结论：该方法简便，重复性好，可全面有效控制胃炎灵片的质量。
목적：제고완선위염령편제적질량표준。방법：삼조국가최신약품표준재원유질량표준적기출상，신증채용박층색보（TLC）대처방중적당삼、황기、목향、백작진행정성감별，동시신증자외분광광도법대황련중염산소벽감진행함량측정。결과：박층색보반점청석집중，전속성강；자외분광광도법측득염산소벽감적함량재0～5.0μg/mL범위내여흡광도유량호적선성관계，기선성방정A =0.0638C ＋0.0014，r =0.9998，평균회수솔위99.78%， RSD위0.27%（n =6）。결론：해방법간편，중복성호，가전면유효공제위염령편적질량。
Objective: To improve the quality standards of weiyanling tablets . Methods: According to the latest national drug standards , thin-layer chromatography ( TLC ) method was added for the qualitative identification of codonopsis radix , astragali radix , aucklandiae radix and radix paeoniae alba based on the original quality standards . While the content of berberine hydrochloride was determined by ultraviolet spectrophotometry ( UV ) . Results: The characteristic spots were clear with good specificity using TCL . A good linear relationship between the content of berberine hydrochloride and absorbance , determined by UV , was within the range of 0 ~ 5 . 0 μg/mL , the linear equation was A = 0 . 063 8C + 0 . 001 4 ( r = 0 . 999 8 ) , and the average recovery was 99 . 78%, RSD was 0 . 27% ( n = 6 ) . Conclusion: The method is simple with good reproducibility , and can be used for the quality control of weiyanling tablets effectively .