中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
1期
14-15
,共2页
重组人凝血因子Ⅶa%难治性出血%临床观察
重組人凝血因子Ⅶa%難治性齣血%臨床觀察
중조인응혈인자Ⅶa%난치성출혈%림상관찰
rFⅦa%Intractable blood loss%Clinical observation
目的：观察重组人凝血因子Ⅶa(rFⅦa)治疗难治性出血的临床现状，以增加对该止血药物的认识和理解，促进其临床应用。方法：回顾分析近5年笔者所在医院收治的难治性出血(心外科15例、胸外科10例术后出血和消化道应激性溃疡3例、创伤后凝血功能障碍7例、肝胆外科术后腹腔内出血5例)患者40例，应用rFⅦa治疗，于应用rFⅦa后3 h出血量比用药前3 h出血量、需输血量及总输血量进行对比。结果：38例患者止血成功，2例死亡。结论：使用rFⅦa治疗后38例3 h出血量比用药前3 h出血量明显减少，需输血量及总输血量明显减少。在难治性出血时，当传统方法无法有效止血时，应积极推荐应用重组人凝血因子Ⅶa治疗。
目的：觀察重組人凝血因子Ⅶa(rFⅦa)治療難治性齣血的臨床現狀，以增加對該止血藥物的認識和理解，促進其臨床應用。方法：迴顧分析近5年筆者所在醫院收治的難治性齣血(心外科15例、胸外科10例術後齣血和消化道應激性潰瘍3例、創傷後凝血功能障礙7例、肝膽外科術後腹腔內齣血5例)患者40例，應用rFⅦa治療，于應用rFⅦa後3 h齣血量比用藥前3 h齣血量、需輸血量及總輸血量進行對比。結果：38例患者止血成功，2例死亡。結論：使用rFⅦa治療後38例3 h齣血量比用藥前3 h齣血量明顯減少，需輸血量及總輸血量明顯減少。在難治性齣血時，噹傳統方法無法有效止血時，應積極推薦應用重組人凝血因子Ⅶa治療。
목적：관찰중조인응혈인자Ⅶa(rFⅦa)치료난치성출혈적림상현상，이증가대해지혈약물적인식화리해，촉진기림상응용。방법：회고분석근5년필자소재의원수치적난치성출혈(심외과15례、흉외과10례술후출혈화소화도응격성궤양3례、창상후응혈공능장애7례、간담외과술후복강내출혈5례)환자40례，응용rFⅦa치료，우응용rFⅦa후3 h출혈량비용약전3 h출혈량、수수혈량급총수혈량진행대비。결과：38례환자지혈성공，2례사망。결론：사용rFⅦa치료후38례3 h출혈량비용약전3 h출혈량명현감소，수수혈량급총수혈량명현감소。재난치성출혈시，당전통방법무법유효지혈시，응적겁추천응용중조인응혈인자Ⅶa치료。
Objective:To observe the clinical present situation of recombinant human coagulation factorⅦa in patients with intractable blood loss, increase awareness about the hemoslatic medicine,improve the clinical application.Method:A retrospective analysis was made to investigate the effect about rFⅦa in patients with intractable blood loss in 40 cases.There were 40 cases,15 cases after cardiac surgery,10 cases after chest surgery,5 cases of hepatobiliary,7 cases of coagulation disorders injury,3 cases of gastrointestinal stress ulcer bleeding.40 cases were treated with rFⅦa.The amount of bleeding, the blood transfusion volume,the total volume of blood transfusion 3 hours before treated with rFⅦa contrast 3 hours after treated with rFⅦa.Result:38 cases were cured successfully,2 cases dead.Conclusion:38 cases treated with rFⅦa,after 3 hours the amount of bleeding were sharp reducing,the blood transfusion volume and the total volume of blood transfusion were sharp slowdown.Patients with intractable blood loss,the conventional method unable valid stanch bleeding, ought to positive recommend treaded with rFⅦa.
