CAJ | 학술논문

目的：探讨免疫疗法在再生障碍性贫血中的临床应用效果。方法：以2010年2月-2013年2月笔者所在医院收治的36例再生障碍性贫血患者为研究对象，均使用免疫抑制剂治疗，随访观察治疗效果，分析疗效影响因素。结果：36例患者经治疗后，总有效率达66.67%，治疗后血红蛋白、中性粒细胞、白细胞和血小板计数显著高于治疗前，差异有统计学意义(P<0.05)，治疗过程中出现发热、血清病和皮疹等不良反应，远期并发症1例；单因素分析提示病程、严重感染与否同治疗效果存在显著相关性。结论：免疫疗法是再生障碍性贫血有效方案，病情确定后需及时实施，以提高治疗效果。
목적：탐토면역요법재재생장애성빈혈중적림상응용효과。방법：이2010년2월-2013년2월필자소재의원수치적36례재생장애성빈혈환자위연구대상，균사용면역억제제치료，수방관찰치료효과，분석료효영향인소。결과：36례환자경치료후，총유효솔체66.67%，치료후혈홍단백、중성립세포、백세포화혈소판계수현저고우치료전，차이유통계학의의(P<0.05)，치료과정중출현발열、혈청병화피진등불량반응，원기병발증1례；단인소분석제시병정、엄중감염여부동치료효과존재현저상관성。결론：면역요법시재생장애성빈혈유효방안，병정학정후수급시실시，이제고치료효과。
Objective:To investigate the clinical effect of immunetherapy in aplastic anemia.Method:From February 2010 to February 2013 in our hospital 36 aplastic anemia patients were chose as the research object,using of immunosuppressive therapy,the follow-up treatment effects were observed, efficacy analysis of influencing factors.Result:36 patients after treatment,the total effective rate was 66.67%,after treatment of neutrophil,hemoglobin,white blood cell and platelet count were significantly higher than that before treatment,the differences were statistically significant(P<0.05),fever,skin rash,serum sickness and no adverse reaction during the treatment,1 case of complications.Single factor analysis showed that the course of disease,severe infection and no significant correlation with therapeutic effect.Conclusion:Immune therapy is effective for regeneration barrier anemia,illness determine after the need for timely implementation,in order to improve the treatment effect.