中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
1期
130-130,131
,共2页
HBV-DNA含量%HBsAg阳性孕妇%乙肝免疫球蛋白%母婴垂直传播
HBV-DNA含量%HBsAg暘性孕婦%乙肝免疫毬蛋白%母嬰垂直傳播
HBV-DNA함량%HBsAg양성잉부%을간면역구단백%모영수직전파
HBV-DNA content%HBsAg positive pregnant women%Hepatitis B immune globulin%Maternal infant vertical transmission
目的：探讨HBV-DNA定量与孕妇母婴阻断后的HBV宫内感染的临床观察。方法：将286例HBsAg阳性孕妇分为研究组143例，其中乙肝大三阳46例，乙肝小三阳45例，HBsAg阳性者52例，HBV-DNA定量均高于正常值或几倍不等；对照组143例，其中乙肝大三阳47例，乙肝小三阳50例，HBsAg阳性者46例，HBV-DNA定量均在正常范围内。两组均于孕28、32、36周分别肌注HBIG 200 IU，采用酶联免疫吸附试验检测两组新生儿的五项指标。结果：研究组、对照组新生儿脐血检测结果HBsAg阳性率分别为34.2%、11.2%，两组比较差异有统计学意义(P<0.05)；两组大三阳性率分别为10.9%、12.8%，两组比较差异无统计学意义(P>0.05)。结论：HBV-DNA含量均在正常范围内，HBIG能够有效阻断HBsAg阳性和乙肝小三阳的母婴传播，但不能阻断乙肝大三阳和HBV-DNA定量异常的乙肝小三阳和HBsAg阳性患者的母婴传播。
目的：探討HBV-DNA定量與孕婦母嬰阻斷後的HBV宮內感染的臨床觀察。方法：將286例HBsAg暘性孕婦分為研究組143例，其中乙肝大三暘46例，乙肝小三暘45例，HBsAg暘性者52例，HBV-DNA定量均高于正常值或幾倍不等；對照組143例，其中乙肝大三暘47例，乙肝小三暘50例，HBsAg暘性者46例，HBV-DNA定量均在正常範圍內。兩組均于孕28、32、36週分彆肌註HBIG 200 IU，採用酶聯免疫吸附試驗檢測兩組新生兒的五項指標。結果：研究組、對照組新生兒臍血檢測結果HBsAg暘性率分彆為34.2%、11.2%，兩組比較差異有統計學意義(P<0.05)；兩組大三暘性率分彆為10.9%、12.8%，兩組比較差異無統計學意義(P>0.05)。結論：HBV-DNA含量均在正常範圍內，HBIG能夠有效阻斷HBsAg暘性和乙肝小三暘的母嬰傳播，但不能阻斷乙肝大三暘和HBV-DNA定量異常的乙肝小三暘和HBsAg暘性患者的母嬰傳播。
목적：탐토HBV-DNA정량여잉부모영조단후적HBV궁내감염적림상관찰。방법：장286례HBsAg양성잉부분위연구조143례，기중을간대삼양46례，을간소삼양45례，HBsAg양성자52례，HBV-DNA정량균고우정상치혹궤배불등；대조조143례，기중을간대삼양47례，을간소삼양50례，HBsAg양성자46례，HBV-DNA정량균재정상범위내。량조균우잉28、32、36주분별기주HBIG 200 IU，채용매련면역흡부시험검측량조신생인적오항지표。결과：연구조、대조조신생인제혈검측결과HBsAg양성솔분별위34.2%、11.2%，량조비교차이유통계학의의(P<0.05)；량조대삼양성솔분별위10.9%、12.8%，량조비교차이무통계학의의(P>0.05)。결론：HBV-DNA함량균재정상범위내，HBIG능구유효조단HBsAg양성화을간소삼양적모영전파，단불능조단을간대삼양화HBV-DNA정량이상적을간소삼양화HBsAg양성환자적모영전파。
Objective:To investigate the clinical observation on HBV intrauterine infection of maternal and child block after the implementation of quantitative HBV-DNA with pregnant women.Method:In this paper,286 cases of HBsAg positive pregnant women were divided into the study group(n=143), 46 cases of HBsAg,HBeAg,and HBcAb test positive,45 cases of hepatitis B small Sanyang,52 cases of HBsAg positive,quantitative HBV-DNA was higher than the normal value ora few times ranging from.The control group(n=143),47 cases of HBsAg,HBeAg,and HBcAb test positive,50 cases of hepatitis B small Sanyang,46 cases of HBsAg positive,quantitative HBV-DNA were within the normal range.Among them,the study group and the control group were injected with 200 IU of hepatitis B immunoglobulin for 1 injection at 28th,32th,and 36th weeks of pregnancy respectively.The samples of cord blood from the newborns were collected and tested for HBsAg,HBsAb,HBeAg,HBeAb and HBcAb by ElISA and FQ-PCR.Result:The study group and the control group positive rates of detection results of neonatal cord blood HBsAg were 34.2%,11.2%,there was significant difference(P<0.05).The control group rates of HBsAg,HBeAg and HBcAb test positive were 8.3%,12.8%,there was no significant difference(P>0.05).Conclusion:The content of HBV-DNA are in the normal range,HBIG can effectively block mother to child transmission of HBsAg positive and HBV small sanyang,but not to block mother to child transmission of hepatitis B small three positive and HBsAg positive hepatitis B patients with HBeAg and HBV-DNA quantitative abnormalities.
