广西医学
廣西醫學
엄서의학
GUANGXI MEDICAL JOURNAL
2014年
12期
1703-1705
,共3页
包维莺%胡喜梅%周水阳%柯金%范燕琴%陆翠%王恒石%朱锐锋%刘媛%范璐%肖素芳
包維鶯%鬍喜梅%週水暘%柯金%範燕琴%陸翠%王恆石%硃銳鋒%劉媛%範璐%肖素芳
포유앵%호희매%주수양%가금%범연금%륙취%왕항석%주예봉%류원%범로%초소방
非霍奇金淋巴瘤%T淋巴细胞亚群%NK细胞%免疫球蛋白
非霍奇金淋巴瘤%T淋巴細胞亞群%NK細胞%免疫毬蛋白
비곽기금림파류%T림파세포아군%NK세포%면역구단백
Non-Hodgkin′s lymphoma%T lymphocyte subsets%NK cell%Immunoglobulin
目的：探讨非霍奇金淋巴瘤（ NHL ）免疫功能的变化及其临床意义。方法初治NHL患者50例为实验组，采集静脉血检测T细胞亚群、NK细胞及免疫球蛋白（ Ig）水平，与30名健康对照者进行比较；并对50例患者中不同临床分期、有无B症状及治疗有效无效组进行比较。结果实验组外周血CD4＋、 NK细胞计数及CD4＋／CD8＋比值均明显低于对照组（P＜0．05），实验组与对照组的CD3＋、CD8＋、CD19＋计数比较差异无统计学意义（ P＞0．05）；实验组中，治疗无效组、有B组症状组、Ⅲ＋Ⅳ期组的CD4＋、NK细胞计数及CD4＋／CD8＋比值明显降低（P＜0．05）；实验组与对照组及实验组各亚组间的IgA、IgG 、IgM水平比较，差异均无统计学意义（P＞0．05）。结论 NHL患者存在细胞免疫抑制，其临床分期、治疗疗效与细胞免疫功能有关，而与体液免疫的相关性有待进一步探讨。
目的：探討非霍奇金淋巴瘤（ NHL ）免疫功能的變化及其臨床意義。方法初治NHL患者50例為實驗組，採集靜脈血檢測T細胞亞群、NK細胞及免疫毬蛋白（ Ig）水平，與30名健康對照者進行比較；併對50例患者中不同臨床分期、有無B癥狀及治療有效無效組進行比較。結果實驗組外週血CD4＋、 NK細胞計數及CD4＋／CD8＋比值均明顯低于對照組（P＜0．05），實驗組與對照組的CD3＋、CD8＋、CD19＋計數比較差異無統計學意義（ P＞0．05）；實驗組中，治療無效組、有B組癥狀組、Ⅲ＋Ⅳ期組的CD4＋、NK細胞計數及CD4＋／CD8＋比值明顯降低（P＜0．05）；實驗組與對照組及實驗組各亞組間的IgA、IgG 、IgM水平比較，差異均無統計學意義（P＞0．05）。結論 NHL患者存在細胞免疫抑製，其臨床分期、治療療效與細胞免疫功能有關，而與體液免疫的相關性有待進一步探討。
목적：탐토비곽기금림파류（ NHL ）면역공능적변화급기림상의의。방법초치NHL환자50례위실험조，채집정맥혈검측T세포아군、NK세포급면역구단백（ Ig）수평，여30명건강대조자진행비교；병대50례환자중불동림상분기、유무B증상급치료유효무효조진행비교。결과실험조외주혈CD4＋、 NK세포계수급CD4＋／CD8＋비치균명현저우대조조（P＜0．05），실험조여대조조적CD3＋、CD8＋、CD19＋계수비교차이무통계학의의（ P＞0．05）；실험조중，치료무효조、유B조증상조、Ⅲ＋Ⅳ기조적CD4＋、NK세포계수급CD4＋／CD8＋비치명현강저（P＜0．05）；실험조여대조조급실험조각아조간적IgA、IgG 、IgM수평비교，차이균무통계학의의（P＞0．05）。결론 NHL환자존재세포면역억제，기림상분기、치료료효여세포면역공능유관，이여체액면역적상관성유대진일보탐토。
Objective To investigate the changes of immune function in patients with non-Hodgkin′s lymphoma ( NHL) and its clinical significance .Methods Fifty newly diagnosed NHL patients ( experimental group ) were enrolled in this study and 30 healthy adults served as control .Their venous blood samples were collected to detect the levels of T lymphocyte subsets ,NK cells and immunoglobulin ( Ig ) .The comparative analysis was conducted among patients with different clinical stages ,with B symptoms or not ,and with different curative effects .Results The levels of CD4+,NK cells,CD4+/CD8+of experimental group were significantly lower than those of control group (P<0.05),while there was no significant difference in the levels of CD3+,CD8+and CD19+between experimental group and control group (P>0.05).In the experimental group ,the levels of CD4+,NK cells ,CD4+/CD8+decreased significantly in the uncured patients ,patients with B symptoms,and patients of stageⅢorⅣ(P<0.05).There were no significant differences in the levels of IgA ,IgG and IgM between experimental group and control group as well as among subgroups of experimental group ( P>0 .05 ) . Conclusion The cellular immune response is suppressed in patients with NHL,and the suppression is correlated with clinical stage,B symptoms and curative effect of NHL.But the correlation with humoral immune needs to be further explored .
