CAJ | 학술논문

目的：：观察急性冠状动脉综合征(ACS)患者血浆甲壳质酶蛋白40(YKL-40)、高敏C反应蛋白(hs-CRP )和尿酸(UA)水平，探讨其与冠状动脉病变的相关性。方法：选取ACS患者102例，其中急性心肌梗死(AMI)48例，不稳定心绞痛(UAP)54例分别作为AMI组和UAP组，所有患者均经冠状动脉造影证实，根据冠状动脉病变支数分为单支病变亚组43例、双支病变亚组37例和多支病变亚组22例；另选52例冠状动脉正常者作为对照组。 ELISA法检测血浆YKL-40、hs-CRP和UA水平。结果：AMI组YKL-40、hs-CRP和UA水平与UAP组及对照组差异均有统计学意义(P<0.01)；ACS组亚组血浆YKL-40和hs-CRP水平随冠状动脉病变支数的增加而升高，各亚组间除AMI组与UAP组比较UA差异无统计学意义(P>0.05)外，余差异均有统计学意义(P<0.01)；ACS患者血浆YKL-40水平与hs-CRP、UA和冠状动脉病变支数均呈正相关关系(P<0.05)。结论：YKL-40升高可能预示着ACS患者的不稳定状态，且与冠心病发病及病变程度密切相关。
목적：：관찰급성관상동맥종합정(ACS)환자혈장갑각질매단백40(YKL-40)、고민C반응단백(hs-CRP )화뇨산(UA)수평，탐토기여관상동맥병변적상관성。방법：선취ACS환자102례，기중급성심기경사(AMI)48례，불은정심교통(UAP)54례분별작위AMI조화UAP조，소유환자균경관상동맥조영증실，근거관상동맥병변지수분위단지병변아조43례、쌍지병변아조37례화다지병변아조22례；령선52례관상동맥정상자작위대조조。 ELISA법검측혈장YKL-40、hs-CRP화UA수평。결과：AMI조YKL-40、hs-CRP화UA수평여UAP조급대조조차이균유통계학의의(P<0.01)；ACS조아조혈장YKL-40화hs-CRP수평수관상동맥병변지수적증가이승고，각아조간제AMI조여UAP조비교UA차이무통계학의의(P>0.05)외，여차이균유통계학의의(P<0.01)；ACS환자혈장YKL-40수평여hs-CRP、UA화관상동맥병변지수균정정상관관계(P<0.05)。결론：YKL-40승고가능예시착ACS환자적불은정상태，차여관심병발병급병변정도밀절상관。
Objective:To explore the correlations between the plasma levels of enzyme chitin 40(YKL-40),high-sensitivity C-reactive protein(hs-CRP),uric acid(UA) and coronary lesions in patients with acute coronary syndrome(ACS). Methods:One hundred and two patients with acute coronary syndrome( ACS) identified by coronary arteriography including 48 cases of acute myocardial infarction (AMI) and 54 cases of unstable angina pectoris(UAP) and 52 healthy adults were divided into the ACS group and control group, respectively. The ACS group were divided into the single-vessel lesion subgroup(43 cases),double-vessel lesions subgroup(37 cases) and multi-vessel lesions subgroup(22 cases) according to the number of coronary artery lesions. The plasma levels of YKL-40,hs-CRP and UA in two groups were measured by enzymelinked immunosorbent assay( ELISA) . Results:The differences of the plasma levels of YKL-40,hs-CRP and UA between the AMI patients,UAP patients and control group were statistically significant(P<0. 01). With the increasing of the number of coronary artery lesions,the levels of YKL-40 and hs-CRP in ACS group increased. The differences of the levels of UA in the subgroups of ACS group were not statistically significant(P>0. 05),but for the levels of YKL-40 and hs-CRP,its differences were statistically significant(P<0. 01). The plasma levels of YKL-40,hs-CRP and UA were positively correlated with the number of coronary artery lesions(P<0. 05). Conclusions:The level of YKL-40 increasing can hint the unstable status of coronary artery in ACS patients,which is closely associated with the coronary heart disease and its severity.