CAJ | 학술논문

目的：：探讨环磷酰胺联合大剂量甲泼尼龙治疗对百草枯中毒患者血清金属蛋白酶9( MMP-9)水平的影响。方法：选择急性百草枯中毒患者50例为研究对象，所有患者在常规治疗联合血液灌流基础上联合环磷酰胺及大剂量甲泼尼龙治疗。检测患者治疗前后血清MMP-9的变化。结果：治疗后血清MMP-9的水平均较治疗前明显降低(P<0.01)。结论：环磷酰胺联合大剂量甲泼尼龙能有效降低百草枯中毒患者血清 MMP-9的水平，血清MMP-9水平降低可能是减轻肺损伤的机制之一。
목적：：탐토배린선알연합대제량갑발니룡치료대백초고중독환자혈청금속단백매9( MMP-9)수평적영향。방법：선택급성백초고중독환자50례위연구대상，소유환자재상규치료연합혈액관류기출상연합배린선알급대제량갑발니룡치료。검측환자치료전후혈청MMP-9적변화。결과：치료후혈청MMP-9적수평균교치료전명현강저(P<0.01)。결론：배린선알연합대제량갑발니룡능유효강저백초고중독환자혈청 MMP-9적수평，혈청MMP-9수평강저가능시감경폐손상적궤제지일。
Objective:To explore the effects of cyclophosphamide combined with large doses of methylprednisolone on the serum level of matrix metalloproteinase 9(MMP-9) of patients with paraquat poisoning. Methods:Fifty patients with acute paraquat poisoning were treated with cyclophosphamide combined with large doses of methylprednisolone on the basis of additional treatment. The levels of serum MMP-9 in all patients were detected before and after treatment. Results:Compared with before treatment,the serum levels of MMP-9 in patients decreased significantly after treatment(P<0. 01). Conclusions:The treatment of cyclophosphamide combined with large doses of methylprednisolone can effectively reduce the serum levels of MMP-9 in patients with paraquat poisoning,which maybe one of the mechanisms of reducing lung injury.