CAJ | 학술논문

目的：：探讨2型糖尿病肾病发生的危险因素。方法：根据24 h尿微量白蛋白( UAlb)定量检测结果，将120例2型糖尿病患者分为2型糖尿病( DM )组60例和2型糖尿病并发糖尿病肾病( DN )组60例，观察2组患者的年龄、病程、收缩压(SBP)、舒张压(DBP)、体质量指数、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、三酰甘油(TC)、总胆固醇(TG)等指标的差异，并采用多因素非条件logistic回归分析DN与各因素的相关性。结果：DN组患者的病程较DM组长(P<0.01)，年龄、SBP、DBP和FPG均高于DM组(P<0.05~P<0.01)；logistic回归分析显示：病程、SBP、DBP、HbA1c、TG和TC均为DN发生的独立危险因素(P<0.01)。结论：年龄、病程、高血糖、高血压及脂代谢紊乱是2型糖尿病肾病发生的危险因素。
목적：：탐토2형당뇨병신병발생적위험인소。방법：근거24 h뇨미량백단백( UAlb)정량검측결과，장120례2형당뇨병환자분위2형당뇨병( DM )조60례화2형당뇨병병발당뇨병신병( DN )조60례，관찰2조환자적년령、병정、수축압(SBP)、서장압(DBP)、체질량지수、공복혈당(FPG)、당화혈홍단백(HbA1c)、삼선감유(TC)、총담고순(TG)등지표적차이，병채용다인소비조건logistic회귀분석DN여각인소적상관성。결과：DN조환자적병정교DM조장(P<0.01)，년령、SBP、DBP화FPG균고우DM조(P<0.05~P<0.01)；logistic회귀분석현시：병정、SBP、DBP、HbA1c、TG화TC균위DN발생적독립위험인소(P<0.01)。결론：년령、병정、고혈당、고혈압급지대사문란시2형당뇨병신병발생적위험인소。
Objective:To investigate the risk factors of diabetic nephropathy in patients with type 2 diabetes mellitus. Methods:One hundred and twenty type 2 diabetic patients were divided into type 2 diabetes mellitus group ( DM group, 60 cases ) and diabetic nephropathy group( DN group,60 cases) according to the level 24 h urine micro albumin( UAlb) . The age,course of disease,and levels of blood pressure,body mass index(BMI),fasting plasma glucose(FPG),glycosylated hemoglobin A1c(HbA1c),triglyceride(TC) and total cholesterol( TG) in all cases were observed. The correlations of DN with each factor were analyzed using multi-factor unconditioned logistic regression analysis. Results:The course of disease in DN group was longer than that in DM group(P<0. 01). Compared with DM group,the means of age,and levels of SBP,DBP and FPG in DN group were higher(P<0. 01 to P<0. 05). Logistic regression analysis showed that the course of disease,SBP,DBP,TG and TC were the independent risk factor of DN(P<0. 01). Conclusions:Age,course of disease,hyperglycaemia,hypertension and dyslipidemia are the risk factors of type 2 diabetic nephropathy.