CAJ | 학술논문

目的：探讨2型糖尿病患者外周血白细胞计数及其相关影响因素。方法采用随机整群抽样方法，对崇明县城桥镇40～70岁2270名常住居民进行调查，内容包括体格检查、75 g葡萄糖口服耐量试验、血常规和血脂等生化检查。结果2270名居民检出2型糖尿病655例，无糖尿病1615例。单因素分析显示2型糖尿病组的血压、体重指数（BMI）、白细胞计数（WBC）、中性粒细胞计数（NEUT）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）明显高于无糖尿病组（P＜0．05），而高密度脂蛋白胆固醇（HDL-C）则明显低于无糖尿病组（P＜0．01）。多元回归分析显示WBC、BMI、餐后2 h血糖（2hPG）、TG、TC、NEUT是2型糖尿病的危险因素。结论2型糖尿病患者可能存在慢性炎症状态，炎症反应在糖尿病的发生发展中起到重要作用。
목적：탐토2형당뇨병환자외주혈백세포계수급기상관영향인소。방법채용수궤정군추양방법，대숭명현성교진40～70세2270명상주거민진행조사，내용포괄체격검사、75 g포도당구복내량시험、혈상규화혈지등생화검사。결과2270명거민검출2형당뇨병655례，무당뇨병1615례。단인소분석현시2형당뇨병조적혈압、체중지수（BMI）、백세포계수（WBC）、중성립세포계수（NEUT）、총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL-C）명현고우무당뇨병조（P＜0．05），이고밀도지단백담고순（HDL-C）칙명현저우무당뇨병조（P＜0．01）。다원회귀분석현시WBC、BMI、찬후2 h혈당（2hPG）、TG、TC、NEUT시2형당뇨병적위험인소。결론2형당뇨병환자가능존재만성염증상태，염증반응재당뇨병적발생발전중기도중요작용。
Objective To investigate peripheral white blood cell (WBC) count and its related influencing factors among patients with type 2 dibetes mellitus(T2DM).Methods Random cluster sampling was adopted to conduct a survey among 2270 residents aged from 40 to 70 years in Chengqiao Town,Chongming County.The items of questionnaire included physical examination ,75g oral glucose tolerance test ,and biochemical examination including routine blood test and serum lipid.Results Among 2270 residents,655 with T2DM and 1615 without diabetes mellitus.The result of univariate analysis showed that blood pressure,body mass index(BMI),WBC,neutrophil(NEUT),total cholesterol(TC),triglyceride(TG) and low density lipoprotein cholesterol ( LDL-C) in T2DM residents were higher than those in the residents without diahetes mellitus(P<0.05),while high density lipoprotein cholesterol (HDL-C) in T2DM residents was significantly lower than that in the residents without diahetes mellitus ( P<0 .001 ) .The result of multiple regression analysis showed that WBC,BMI,2-hour plasma glucose(2hPG),TG,TC and NEUT were risk factors for T2DM.Conclusion Patients with T2DM might suffer from chronic inflammation ,and inflammatory reaction plays an important role in the occurrence and development of diabetes .