CAJ | 학술논문

目的：探讨小剂量合贝爽联合培哚普利治疗老年单纯收缩期高血压的临床疗效。方法选取2012年8月至2014年8月之间在我院接受治疗的120例老年单纯收缩期高血压患者为观察对象，随机均分为三组，分别接受小剂量合贝爽、培哚普利、小剂量合贝爽联合培哚普利治疗12周，观察治疗前后三组收缩压、舒张压、脉压差、尿微量白蛋白变化，同时观察三组患者治疗后不良反应。结果联合治疗组的疗效显著高于小剂量合贝爽组和培哚普利组，三组患者的血压均显著下降与治疗前对比（P＜0.05）；联合治疗组患者的收缩压和脉压差与小剂量合贝爽组对比（P＜0.05）；与培哚普利组对比，脉压差改善明显（P<0.05）；收缩压改善程度对比（P＞0.05）。三组患者的舒张压水平对比（P＞0.05）；与治疗前对比，三组患者的尿微量白蛋白水平显著降低（P＜0.05）；联合治疗组与小剂量合贝爽组及培哚普利组比较，尿微量白蛋白水平均显著降低，差异具有统计学意义（P＜0.05）。三组患者治疗后均未出现明显不良反应。结论老年单纯收缩期高血压患者接受小剂量合贝爽联合培哚普利治疗，明显降低患者收缩压及脉压差，降低尿微量尿蛋白，服药简便，安全有效。
목적：탐토소제량합패상연합배타보리치료노년단순수축기고혈압적림상료효。방법선취2012년8월지2014년8월지간재아원접수치료적120례노년단순수축기고혈압환자위관찰대상，수궤균분위삼조，분별접수소제량합패상、배타보리、소제량합패상연합배타보리치료12주，관찰치료전후삼조수축압、서장압、맥압차、뇨미량백단백변화，동시관찰삼조환자치료후불량반응。결과연합치료조적료효현저고우소제량합패상조화배타보리조，삼조환자적혈압균현저하강여치료전대비（P＜0.05）；연합치료조환자적수축압화맥압차여소제량합패상조대비（P＜0.05）；여배타보리조대비，맥압차개선명현（P<0.05）；수축압개선정도대비（P＞0.05）。삼조환자적서장압수평대비（P＞0.05）；여치료전대비，삼조환자적뇨미량백단백수평현저강저（P＜0.05）；연합치료조여소제량합패상조급배타보리조비교，뇨미량백단백수평균현저강저，차이구유통계학의의（P＜0.05）。삼조환자치료후균미출현명현불량반응。결론노년단순수축기고혈압환자접수소제량합패상연합배타보리치료，명현강저환자수축압급맥압차，강저뇨미량뇨단백，복약간편，안전유효。
Objective To investigate the clinical efficacy of low-dose Herbesser combined with perindopril in the treatment of isolated systolic hypertension (ICH) in the elderly. Methods One hundred and twenty elderly patients with ICH who were admitted to our hospital from August 2012 to August 2014 were randomly and equally divided into three groups. These groups received low-dose Herbesser, perindopril, and low-dose Herbesser combined with perindopril for 12 weeks, respectively. Systolic pressure, diastolic pressure, pulse pressure, and urinary albumin levels in the three groups were measured before and after treatment. Adverse reactions in the three groups were also observed after treatment. Results The efficacy of combined therapy was significantly better than that of low-dose Herbesser alone and perindopril alone. Blood pressure values in the three groups significantly decreased after treatment (P<0.05). Patients treated with combined therapy had significant improvements in systolic pressure and pulse pressure compared with those treated with low-dose Herbesser alone (P<0.05). Compared with those treated with perindopril alone, patients treated with combined therapy showed a significant improvement in pulse pressure (P<0.05), rather than systolic pressure (P>0.05). There was no significant difference in diastolic pressure between the three groups (P>0.05). Urinary albumin levels in the three groups decreased significantly after treatment (P<0.05). The combined therapy group had a significantly lower urinary albumin level after treatment compared with the low-dose Herbesser group and perindopril group (P<0.05). There were no obvious adverse reactions in the three groups after treatment. Conclusion Elderly patients with ICH have significantly reduced systolic pressure, pulse pressure, and urinary albumin levels after treatment with low-dose Herbesser combined with perindopril. This combined medication is simple, safe, and effective.