CAJ | 학술논문

目的：探讨激素对口腔黏膜扁平苔藓（OLP）患者治疗前后Th1/Th2比值及T细胞因子的表达变化及临床疗效。方法随机选取本院诊断为OLP的患者50例作为治疗组，并选取同期体检健康者50例作为对照组，治疗组患者采用地塞米松注射液治疗4周。比较治疗前、治疗后4周两组研究对象Th1/Th2比值、干扰素（IFN）-γ、IFN-α等细胞因子水平的差异，并观察治疗组的治疗效果。结果治疗组患者治疗前Th1、Th2水平分别为（79.15±7.84）、（57.77±4.66）pg/ml，治疗后Th1、Th2水平明显降低[（18.44±2.14）、（15.91±2.15）pg/ml]，差异具有显著性（P＜0.05）；治疗组患者治疗前后Th1、Th2、Th1/Th2比值均显著高于对照组4周前及未经任何处置的4周后，差异具有显著性（P＜0.05）。治疗组患者治疗前后IFN-γ、白细胞介素（IL）-2、IL-4、IL-10水平与对照组（4周后与之前数据相同）比较差异无显著性（P＞0.05）；治疗组患者治疗前后IFN-α、IL-6、IL-8水平均显著高于对照组（4周后与之前数据相同），差异具有显著性（P＜0.05）。50例OLP患者治愈28例（56%）、有效19例（38%）、无效3例（6%）。结论 Th1/Th2比值、IFN-γ、IL-2、IL-4、IL-10与OLP病情密切相关，病情越严重，上述指标表达水平越高。
목적：탐토격소대구강점막편평태선（OLP）환자치료전후Th1/Th2비치급T세포인자적표체변화급림상료효。방법수궤선취본원진단위OLP적환자50례작위치료조，병선취동기체검건강자50례작위대조조，치료조환자채용지새미송주사액치료4주。비교치료전、치료후4주량조연구대상Th1/Th2비치、간우소（IFN）-γ、IFN-α등세포인자수평적차이，병관찰치료조적치료효과。결과치료조환자치료전Th1、Th2수평분별위（79.15±7.84）、（57.77±4.66）pg/ml，치료후Th1、Th2수평명현강저[（18.44±2.14）、（15.91±2.15）pg/ml]，차이구유현저성（P＜0.05）；치료조환자치료전후Th1、Th2、Th1/Th2비치균현저고우대조조4주전급미경임하처치적4주후，차이구유현저성（P＜0.05）。치료조환자치료전후IFN-γ、백세포개소（IL）-2、IL-4、IL-10수평여대조조（4주후여지전수거상동）비교차이무현저성（P＞0.05）；치료조환자치료전후IFN-α、IL-6、IL-8수평균현저고우대조조（4주후여지전수거상동），차이구유현저성（P＜0.05）。50례OLP환자치유28례（56%）、유효19례（38%）、무효3례（6%）。결론 Th1/Th2비치、IFN-γ、IL-2、IL-4、IL-10여OLP병정밀절상관，병정월엄중，상술지표표체수평월고。
Objective To discuss therapy of Th1/Th2 in patients with OLP when T cell response patterns and correlation. Method Randomly selected 50 cases of OLP in our hospital as treatment group, 50 cases of normal as control group. Treatment group were treated with dexamethasone injection for 4 weeks. Studied differences between before and after treatment of 4 weeks, two groups of subjects of Th1/Th2 ratio, IFN-γ, IFN-α cytokine, and observed the therapeutic effect of the treatment group. Result Th1, Th2 levels of the treatment group patients before treatment were (79.15±7.84), (57.77±4.66) pg/ml, Th1, Th2 levels were signiifcantly lower after treatment [(18.44±2.14), (15.91±2.15) pg/ml], the difference was signiifcant (P < 0.05); treatment group before and after treatment in patients with Th1, Th2 the ratio of Th1/Th2, respectively, and control group 4 weeks ago and without any disposal compared after 4 weeks, were higher than control group, the difference was signiifcant (P<0.05). Treatment group patients before treatment and after treatment of IFN-γ, IL-2, IL-4, IL-10 and normal control group (4 weeks after and before the same data) no signiifcant difference (P>0.05);treatment group patients before treatment and after treatment of IFN-α, IL-6, IL-8 were signiifcantly higher than those in control group (4 weeks after the data and before the same), the difference was signiifcant (P < 0.05). In 50 OLP patients and 28 cases were cured (56%), effective 19 cases (38%), invalid 3 cases (6%). Conclusion The value of Th1/Th2, IFN-γ, IL-2, IL-4, IL-10 and OLP disease are closely related, the illness is more serious, the higher expression level.