CAJ | 학술논문

目的：建立感冒清胶囊中对乙酰氨基酚质量分数测定方法。方法选用Krommasil C18色谱柱(250 mm×4.6 mm,5μm),以甲醇-水(体积比30∶70)为流动相,检测波长为249 nm,流速为1.0 mL/min。结果对乙酰氨基酚进样量在0.1024~3.0720μg范围内线性关系良好(r=1),平均回收率为99.03%(RSD=1.8%, n=6)。结论本法简便、快捷、稳定、专属性强,可有效控制感冒清胶囊的质量。
목적：건립감모청효낭중대을선안기분질량분수측정방법。방법선용Krommasil C18색보주(250 mm×4.6 mm,5μm),이갑순-수(체적비30∶70)위류동상,검측파장위249 nm,류속위1.0 mL/min。결과대을선안기분진양량재0.1024~3.0720μg범위내선성관계량호(r=1),평균회수솔위99.03%(RSD=1.8%, n=6)。결론본법간편、쾌첩、은정、전속성강,가유효공제감모청효낭적질량。
Objective To establish HPLC method for the determination of paracetamol in Ganmaoqing capsules. Methods Kromasil C18 column (250 mm×4.6 mm, 5 μm)was selected to optimize the HPLC conditions with methanol-water ( 30∶70) as the mobile phase. The detection wavelength was at 249 nm, and the flow rate was 1. 0 mL/min. Results The linear range of paracetamol was 0.102 4-3.072 0 μg (r=1). The average recovery was 99.03% (RSD=1.8%, n=6). Conclusion The method was simple, fast, stable and accurate with high specificity. Therefore, it could be used for the quality control of Ganmaoqing capsules.