CAJ | 학술논문

目的：分析应用中医辨证四季用药治疗慢性肝病的临床效果。方法随机选取本院2011年1月至2012年12月收治的50例慢性肝病患者，按照随机数表法分为A组及B组，每组各25例。A组患者采用中医辨证论治治疗，B组患者在A组基础上联合四季用药治疗。观察两组患者治疗前及治疗12个月后肝功能改善情况、睡眠状态自评量表（SRSS）评分、焦虑自评量表（SAS）评分及治疗期间不良反应发生情况。结果两组患者治疗前丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBIL）、结合胆红素（DBIL）及非结合胆红素（IBIL）水平比较差异均无显著性（P＞0.05），治疗12个月后两组患者上述指标均较治疗前明显改善，且B组改善程度较A组更为明显，差异具有显著性（P＜0.05）；两组患者治疗前SRSS及SAS评分比较差异无显著性（P＞0.05），治疗12个月后SRSS评分及SAS评分均较治疗前明显改善，且B组改善程度较A组更为明显，差异具有显著性（P＜0.05）；A组患者腹泻5例（20.00%），心悸1例（4.00%），尿频2例（8.00%），肾功能不全1例（4.00%）；B组患者腹泻4例（16.00%），心悸1例（4.00%），尿频1例（4.00%），肾功能不全3例（12.00%），两组患者经药物减量后不良反应均得到缓解，且不良反应发生率比较差异无显著性（P＞0.05）。结论中医辨证四季用药治疗慢性肝病效果显著，安全、可靠，值得临床推广应用。
목적：분석응용중의변증사계용약치료만성간병적림상효과。방법수궤선취본원2011년1월지2012년12월수치적50례만성간병환자，안조수궤수표법분위A조급B조，매조각25례。A조환자채용중의변증론치치료，B조환자재A조기출상연합사계용약치료。관찰량조환자치료전급치료12개월후간공능개선정황、수면상태자평량표（SRSS）평분、초필자평량표（SAS）평분급치료기간불량반응발생정황。결과량조환자치료전병안산전안매（ALT）、천동안산전안매（AST）、총담홍소（TBIL）、결합담홍소（DBIL）급비결합담홍소（IBIL）수평비교차이균무현저성（P＞0.05），치료12개월후량조환자상술지표균교치료전명현개선，차B조개선정도교A조경위명현，차이구유현저성（P＜0.05）；량조환자치료전SRSS급SAS평분비교차이무현저성（P＞0.05），치료12개월후SRSS평분급SAS평분균교치료전명현개선，차B조개선정도교A조경위명현，차이구유현저성（P＜0.05）；A조환자복사5례（20.00%），심계1례（4.00%），뇨빈2례（8.00%），신공능불전1례（4.00%）；B조환자복사4례（16.00%），심계1례（4.00%），뇨빈1례（4.00%），신공능불전3례（12.00%），량조환자경약물감량후불량반응균득도완해，차불량반응발생솔비교차이무현저성（P＞0.05）。결론중의변증사계용약치료만성간병효과현저，안전、가고，치득림상추엄응용。
Objective To analyse the clinical effect of TCM drug application of four seasons in the treatment of chronic liver diseases. Method Randomly selected 50 cases of patients with chronic liver disease in our hospital from January 2011 to December 2012, according to the random number table method, 50 cases were divided into group A and group B, 25 cases in each group. Group A of patients were treated with TCM therapy, group B on the basis of group A treated with seasons medication. Two groups of patients were observed before treatment and 12 months after treatment liver function improvement, self rating scale of sleep (SRSS) scale, self rating anxiety (SAS) scale score and the occurrence of adverse reactions during treatment. Result Two groups of patients before treatment, the ALT, AST, TBIL, DBIL and IBIL levels had no signiifcant difference (P >0.05), the above indexes in two groups of patients after 12 months of treatment were signiifcantly improved, the improvement in group B was obvious better than group A, the differences between groups was signiifcant (P<0.05);the difference of SRSS scores and SAS scores before treatment in two groups were not signiifcant (P>0.05), the SRSS scores and SAS scores were signiifcantly improved after treatment in two groups, and group B improved more than group A, the difference was signiifcant (P < 0.05);group A of patients with diarrhea in 5 cases (20.00%), palpitations 1 case (4.00%), frequent urination 2 cases (8.00%), renal insufifciency 1 case (4.00%);group B of patients with diarrhea in 4 cases (16.00%), palpitations 1 patients (4.00%), urinary 1 case (4.00%), renal insufifciency 3 cases (12.00%), after dose reduction, adverse reactions had been alleviated, and the incidence of adverse reactions had no signiifcant difference (P>0.05). Conclusion TCM four medication has remarkable effect for the treatment of chronic liver disease, safe, reliable, worthy of clinical application.