中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
11期
107-109
,共3页
小儿慢性胃炎%克拉霉素%阿莫西林克拉维酸钾分散片
小兒慢性胃炎%剋拉黴素%阿莫西林剋拉維痠鉀分散片
소인만성위염%극랍매소%아막서림극랍유산갑분산편
Children chronic gastritis%Clarithromycin%Amoxicillin clavulanic acid potassium dispersible tablets
目的：观察和分析克拉霉素治疗小儿慢性胃炎的临床效果。方法选取本院2008年5月至2012年10月收治的116例慢性胃炎患儿，按照随机数表法分为对照组和观察组，每组各58例。对照组患儿采用阿莫西林克拉维酸钾分散片治疗，观察组患儿在对照组基础上采用克拉霉素治疗。观察两组患儿治疗前后临床症状和体征改善情况、胃黏膜修复情况、疗效及不良反应发生情况。结果两组患儿治疗后腹痛、食欲不振及大便不调等症状较治疗前显著改善，差异均具有显著性（P＜0.05），且观察组改善显著优于对照组，差异具有显著性（P＜0.05）。观察组患儿胃黏膜修复有效率明显高于对照组，差异具有显著性（P＜0.05）。观察组治疗有效率为96.55%（56/58），与对照组[87.93%（51/58）]比较差异具有显著性（P＜0.05）。治疗期间，对照组患儿3例轻度呕吐，观察组患儿2例腹痛，均未经处理，症状自行消失。本研究出现的轻微症状均未对治疗结果产生影响，两组患儿均未发生明显不良反应。结论克拉霉素辅助治疗可有效改善慢性胃炎患儿腹痛等临床症状，促进患儿胃黏膜修复，提高治疗效果，且无明显不良反应，值得临床推广应用。
目的：觀察和分析剋拉黴素治療小兒慢性胃炎的臨床效果。方法選取本院2008年5月至2012年10月收治的116例慢性胃炎患兒，按照隨機數錶法分為對照組和觀察組，每組各58例。對照組患兒採用阿莫西林剋拉維痠鉀分散片治療，觀察組患兒在對照組基礎上採用剋拉黴素治療。觀察兩組患兒治療前後臨床癥狀和體徵改善情況、胃黏膜脩複情況、療效及不良反應髮生情況。結果兩組患兒治療後腹痛、食欲不振及大便不調等癥狀較治療前顯著改善，差異均具有顯著性（P＜0.05），且觀察組改善顯著優于對照組，差異具有顯著性（P＜0.05）。觀察組患兒胃黏膜脩複有效率明顯高于對照組，差異具有顯著性（P＜0.05）。觀察組治療有效率為96.55%（56/58），與對照組[87.93%（51/58）]比較差異具有顯著性（P＜0.05）。治療期間，對照組患兒3例輕度嘔吐，觀察組患兒2例腹痛，均未經處理，癥狀自行消失。本研究齣現的輕微癥狀均未對治療結果產生影響，兩組患兒均未髮生明顯不良反應。結論剋拉黴素輔助治療可有效改善慢性胃炎患兒腹痛等臨床癥狀，促進患兒胃黏膜脩複，提高治療效果，且無明顯不良反應，值得臨床推廣應用。
목적：관찰화분석극랍매소치료소인만성위염적림상효과。방법선취본원2008년5월지2012년10월수치적116례만성위염환인，안조수궤수표법분위대조조화관찰조，매조각58례。대조조환인채용아막서림극랍유산갑분산편치료，관찰조환인재대조조기출상채용극랍매소치료。관찰량조환인치료전후림상증상화체정개선정황、위점막수복정황、료효급불량반응발생정황。결과량조환인치료후복통、식욕불진급대편불조등증상교치료전현저개선，차이균구유현저성（P＜0.05），차관찰조개선현저우우대조조，차이구유현저성（P＜0.05）。관찰조환인위점막수복유효솔명현고우대조조，차이구유현저성（P＜0.05）。관찰조치료유효솔위96.55%（56/58），여대조조[87.93%（51/58）]비교차이구유현저성（P＜0.05）。치료기간，대조조환인3례경도구토，관찰조환인2례복통，균미경처리，증상자행소실。본연구출현적경미증상균미대치료결과산생영향，량조환인균미발생명현불량반응。결론극랍매소보조치료가유효개선만성위염환인복통등림상증상，촉진환인위점막수복，제고치료효과，차무명현불량반응，치득림상추엄응용。
Objective Clinical effect observation and analysis of clarithromycin in treatment of children with chronic gastritis. Method Selected the hospital from May 2008 to October 2012 were treated 116 cases of children with chronic gastritis, according to a random number table divided into control group and observation group, 58 cases in each group. Control group were treated with amoxicillin, clavulanate potassium tablet, compound acidophilus tablets in the treatment, patients were observed in the treatment group were treated with clarithromycin group basis. Clinical symptoms observed two groups of patients before and after treatment, gastric mucosal repair, clinical efifcacy, adverse reactions. Result After the two groups of children treat abdominal pain, loss of appetite and stool and other significant improvements before the symptoms are more treatment, the differences were statistically signiifcant (P<0.05), and the observed improvement was signiifcantly better than control group, the difference was signiifcant (P < 0.05). The effective rate of gastric mucosal repair in observation group was significantly better than control group, the difference was significant (P < 0.05). In addition, observation group therapy effective rate was 96.55%(56/58) and control group was [87.93%(51/58)], the difference was signiifcant (P<0.05). During treatment, three cases in control group of children with mild vomiting, abdominal pain observation group of children two cases the symptoms go away without treatment. Mild symptoms in this study were not appearing impact on treatment outcome, the two groups of children with no obvious adverse reactions. Conclusion Clarithromycin adjuvant therapy can effectively improve the clinical symptoms in children with abdominal pain, chronic gastritis, gastric mucosa in children promote repair, improve the therapeutic effect, and no signiifcant adverse reactions, worthy of clinical application.
