CAJ | 학술논문

目的：探讨埃兹蛋白（ Ezrin ）和基质金属蛋白酶－9（ MMP－9）在甲状腺乳头状癌（ papillary thyroid carcinomas ， PTC）组织中的表达及意义。方法：采用免疫组化MaxVision法检测50例PTC组织、22例甲状腺腺瘤组织和28例切除的健侧腺叶正常甲状腺组织中Ezrin、MMP－9的表达，分析其表达与PTC临床病理特征的关系及二者表达的相关性。结果：Ezrin、MMP－9在PTC组织的阳性率均明显高于在甲状腺腺瘤及正常甲状腺组织，且其高表达与肿瘤淋巴结转移密切相关（ P＜0.05）；Ezrin与MMP－9表达呈正相关（ P＜0.05）。结论：Ezrin和MMP－9的过表达可能与PTC的发生发展、侵袭转移有关，二者有望成为判定PTC及预测其侵袭转移能力的指标。
목적：탐토애자단백（ Ezrin ）화기질금속단백매－9（ MMP－9）재갑상선유두상암（ papillary thyroid carcinomas ， PTC）조직중적표체급의의。방법：채용면역조화MaxVision법검측50례PTC조직、22례갑상선선류조직화28례절제적건측선협정상갑상선조직중Ezrin、MMP－9적표체，분석기표체여PTC림상병리특정적관계급이자표체적상관성。결과：Ezrin、MMP－9재PTC조직적양성솔균명현고우재갑상선선류급정상갑상선조직，차기고표체여종류림파결전이밀절상관（ P＜0.05）；Ezrin여MMP－9표체정정상관（ P＜0.05）。결론：Ezrin화MMP－9적과표체가능여PTC적발생발전、침습전이유관，이자유망성위판정PTC급예측기침습전이능력적지표。
Objective:To explore the expressions and significance of Ezrin and MMP -9 protein in papillary thyroid carcinomas.Methods:The expressions of Ezrin and MMP -9 protein in 50 cases of PTC tissues , 22 cases of thyroid adenoma and 28 cases of resection of the contralateral lobe of normal thyroid tissue were detected by immunostoemical MaxVision method .The relation-ship between Ezrin and MMP -9 expression and clinical data were also analysed.Results:The positive expression rate of Ezrin and MMP-9 protein in PTC was significantly higher than that in thyroid adenoma and normal thyroid tissue , and the high expression of Ezrin and MMP-9 in PTC correlated with lymph node metastasis(P<0.05).The expression of Ezrin has positive correlation with the expression of MMP-9( P<0.05).Conclusion:Over expression of Ezrin and MMP-9 may be relation with evolution and metastasis of PTC.Ezrin and MMP-9 could be a marker to diagnose PTC and evaluate invasion and metastasis in PTC.